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  1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor

5-HT Receptor

5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, including glutamate, GABA, dopamine, epinephrine / norepinephrine, and acetylcholine, as well as many hormones, including oxytocin, prolactin, vasopressin, cortisol, corticotropin, and substance P, among others. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.

5-HT Receptor 相关产品 (227):

Cat. No.Product NameEffectPurity
  • HY-17366
    Clozapine N-oxideAntagonist 99.98%
    Clozapine N-oxide (CNO) 是抗精神病药物氯氮平的主要代谢产物。 Clozapine N-oxide是 DREADD 系统的激动剂。
  • HY-B0407A
    Chlorpromazine hydrochlorideAntagonist 99.83%
    Chlorpromazine Hydrochloride是D25HT2A钾通道钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。
  • HY-N0737A
    HarmineInhibitor 99.78%
    Harmine是一种具有抗癌和抗炎活性的天然双特异性酪氨酸磷酸化调节激酶 ((DYRK)) 抑制剂。
  • HY-N0296A
    Scopolamine hydrobromideInhibitor >98.0%
    Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3受体反应,IC50 为 2.09 μM。
  • HY-B1473
    Serotonin hydrochlorideAgonist 99.97%
    Serotonin hydrochloride 是 CNS 中的单胺神经递质和内源性 5-HT 受体激动剂。Serotonin hydrochloride 也是儿茶酚 O-甲基转移酶 (COMT) 的抑制剂其 Ki 值为 44 μM。
  • HY-B1541
    BemesetronAntagonist >99.0%
    Bemesetron (MDL 72222) 是一种选择性 5-HT3受体拮抗剂,IC50 为 0.33 nM 。具有神经保护作用。
  • HY-14785A
    Befiradol hydrochlorideAgonist 99.22%
    Befiradol hydrochloride (NLX-112 hydrochloride) 是选择性的5-羟色胺 1A (5-HT)1A 受体激动剂。
  • HY-112707
    AM9405Agonist
    AM9405是一种新型的外周活性大麻素1型 (CB1)5-羟色胺3型受体激动剂。 AM9405抑制回肠和结肠的抽搐收缩,IC50分别为45.71 和 0.076 nM。
  • HY-14557
    PimavanserinInhibitor 99.73%
    Pimavanserin是选择性的 5-HT2A受体反向激动剂,pIC50pKd 分别为8.73 and 9.3。
  • HY-B1272
    Desipramine hydrochlorideInhibitor 99.68%
    Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET), 5-羟色胺转运体 (SERT) 和多巴胺转运 (DAT) 的抑制剂,其 Ki 值分别为 4, 61 和 78,720 nM。
  • HY-14541
    OlanzapineAntagonist 99.94%
    Olanzapine(LY170053)是5-HT2和D2受体高亲和性拮抗剂。
  • HY-14546
    AripiprazoleAgonist 99.98%
    Aripiprazole (OPC-14597) 是人5-HT1A受体部分激动剂,Ki 为4.2 nM。
  • HY-B0965
    Thioridazine hydrochlorideAntagonist 99.93%
    Thioridazine是一种治疗精神类疾病的药物, 如精神分裂症, 具有多巴胺D4受体选择性和5-羟色胺拮抗作用。
  • HY-11018
    RisperidoneInhibitor 99.16%
    Risperidone是 5-HT2受体的阻断剂,P-糖蛋白(P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2受体的Ki 值分别为 4.8,5.9 nM。
  • HY-15780
    BrexpiprazoleModulator 99.38%
    Brexpiprazole是人 5-HT1A多巴胺受体的部分激动剂,Ki分别为0.12 nM 和 0.3 nM。 Brexpiprazole也是 5-HT2A受体的拮抗剂,Ki 为0.47 nM。
  • HY-N0060A
    Ferulic acid sodiumActivator 99.74%
    Ferulic acid (sodium) 是一种酚类化合物,能够抑制由氧化应激和炎症产生的机体紊乱。
  • HY-14763A
    Cariprazine hydrochlorideModulator 99.89%
    Cariprazine(RGH188)盐酸盐有抗精神病活性,对D3和D2受体有较高亲和力,Ki分别为0.09 nM和0.5 nM,对5-HT(1A)受体有一定亲和力。
  • HY-14763
    CariprazineModulator 98.01%
    Cariprazine是一种新型抗精神病候选药物,结合D3,D25-HT1AKi 为0.085 nM,0.49 nM,2.6 nM。
  • HY-14543
    SertindoleAntagonist
    Sertindole是5-HT2A,5-HT2C,D2和αl受体拮抗剂。
  • HY-B0478
    Trazodone hydrochlorideAntagonist 99.95%
    Trazodone (hydrochloride) (AF-1161) 是5 羟色胺受体拮抗剂和重吸收抑制剂,可作用于焦虑症。
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