快乐彩|快乐彩走势图|快乐彩玩法技巧_百度搜狗

  1. Neuronal Signaling
  2. AChE

AChE

Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE 相关产品 (40):

Cat. No.Product NameEffectPurity
  • HY-76299
    GalanthamineInhibitor 99.43%
    Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,IC50 为 500 nM。
  • HY-B0034
    Donepezil HydrochlorideInhibitor 99.97%
    Donepezil(E 2020)盐酸盐是非竞争性的AChE抑制剂,能穿过血脑屏障,增加皮质中的乙酰胆碱水平。
  • HY-B0943
    MalathionInhibitor >98.0%
    Malathion是一种有机磷酸酯的副交感神经药物,不可逆地与胆碱酯酶结合,是一种杀虫剂,具有相对较低的人体毒性。
  • HY-17552
    sn-Glycero-3-phosphocholineActivator >98.0%
    L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)是存在于脑和奶中的天然胆碱化合物,也是拟副交感神经乙酰胆碱前体。
  • HY-17368
    RivastigmineInhibitor 99.39%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-B1626A
    Demecarium BromideInhibitor
    Demecarium Bromide (BC-48) 是一种有效的 cholinesterase抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。
  • HY-N0226
    EpiberberineInhibitor
    Epiberberine 是从黄连中得到的生物碱,为有效的 AChEBChE抑制剂,和非竞争性的BACE1抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine 具有抗氧化作用,能够清除 ONOO-(IC50,16.83 μM),对阿尔滋海默症和糖尿病有潜在治疗作用。在 3T3-
  • HY-B0942
    Benzethonium chlorideInhibitor >98.0%
    Benzethonium chloride作用于在爪蟾卵母细胞,抑制人重组α7和α4β2神经元烟碱性乙酰胆碱受体。
  • HY-A0009
    Galanthamine hydrobromideInhibitor 99.53%
    Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。
  • HY-17388
    (±)-Huperzine AInhibitor >98.0%
    Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-B2244
    Tacrine hydrochloride hydrateInhibitor 99.98%
    Tacrine hydrochloride hydrate 是乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂,其 IC50 值分别为 31 nM 和 25.6 nM。
  • HY-14566
    DonepezilInhibitor 99.87%
    Donepezil(E 2020)是AChE抑制剂,对bAChE和hAChE的IC50分别为8.12 nM和11.6 nM。
  • HY-17387
    (-)-Huperzine AInhibitor >98.0%
    Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-N0342
    ScopoletinInhibitor 99.57%
    Scopoletin 是一种乙酰胆碱酯酶 (AChE) 抑制剂。
  • HY-B0207A
    Pyridostigmine bromideInhibitor >98.0%
    Pyridostigmine是可逆的胆碱酯酶抑制剂。
  • HY-B0949
    Protriptyline hydrochlorideInhibitor 99.91%
    Protriptyline是一种三环抗抑郁药(TCA),含有一个仲胺,治疗抑郁和ADHD。与其他抗抑郁药相比是独一无二的,Protriptyline是激励代替镇静,并且有时用于嗜睡症,实现促醒效果。
  • HY-N0285
    ImperatorinInhibitor 98.11%
    Imperatorin 是一种有效的 NO synthesis抑制剂,IC50 为 9.2 μmol,也是 BChE抑制剂,IC50 为 31.4 μmol。Imperatorin 是 TRPV1的微弱激动剂,EC50 为 12.6±3.2 μM。
  • HY-11017
    Rivastigmine tartrateInhibitor 98.53%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-N0226A
    Epiberberine chlorideInhibitor 99.60%
    Epiberberine chloride 是从黄连中得到的生物碱,为有效的 AChEBChE抑制剂,和非竞争性的BACE1抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine chloride 具有抗氧化作用,能够清除 ONOO-(IC50,16.83 μM),对阿尔滋海默症和糖尿病有潜在治疗作用
  • HY-B1200
    Pralidoxime chlorideActivator >99.0%
    Pralidoxime chloride属于肟类化合物, 有效治疗有机磷中毒,对中毒乙酰胆碱酯酶具有恢复作用。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.