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  1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR

ATM/ATR

ATM/ATR are members of the PI3 family of serine-threonine kinases and function as essential links between the sensors and effectors of the DNA damage response. The roles of ATM and ATR partially overlap and are cooperative; however they are also known to play distinct roles in protecting the cell from DNA damage. ATM is mostly responsible for sending signals from DSBs (double-strand breaks) induced by ionizing radiation while the closely related ATR responds to UV damage or stalled replication forks. ATM and ATR are known to phosphorylate common as well as specific substrates to activate checkpoint signaling. The G1, S, and G2 cell cycle checkpoints are primarily regulated by the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases.

ATM/ATR Isoform Specific Products:

  • ATM

  • ATR

ATM/ATR 相关产品 (17):

Cat. No.Product NameEffectPurity
  • HY-10197
    WortmanninInhibitor 99.85%
    Wortmannin 是一种多靶点抑制剂。Wortmannin 抑制 PI3KMLCKDNA-PKATMATRPolo-like kinase 3(Plk3),IC50 分别为 3 nM,200 nM,16 nM,150 nM,1.8 μM 和 48 nM。
  • HY-19323
    CeralasertibInhibitor 99.76%
    Ceralasertib (AZD6738) 是有效地 ATR激酶抑制剂,IC50 值为 1 nM。
  • HY-13902
    BerzosertibInhibitor 99.22%
    Berzosertib (VE-822) 是一种 ATR抑制剂,Ki值小于0.2 nM。也可抑制 ATMKi 为 34 nM。
  • HY-12016
    KU-55933Inhibitor 99.67%
    KU-55933 是有效的 ATM抑制剂,IC50Ki 值分别为 12.9 和 2.2 nM;对 ATM 的选择性比对 DNA-PK,PI3K/PI4K,ATR 和 mTOR 高。
  • HY-14731
    VE-821Inhibitor 99.47%
    VE-821 是一种有效的 ATP 竞争性的 ATR抑制剂,Ki/IC50 为 13 nM/26 nM。
  • HY-112614
    ATM Inhibitor-1Inhibitor
    ATM Inhibitor-1 是一种有效、选择性、可口服的 ATM抑制剂,IC50 值为 0.7 nM,对 mTOR (IC50,21 μM),DNAPK (IC50,2.8 μM),PI3Kα (IC50,3.8 μM),PI3Kβ (IC50,10.3 μM),PI3Kγ (IC50,3 μM) 和 PI3Kδ (IC50
  • HY-101566
    BAY-1895344Inhibitor
    BAY-1895344 是一种有效、可口服、选择性的 ATR抑制剂,IC50 值为 7 nM。具有抗肿瘤活性。
  • HY-12061
    KU-60019Inhibitor 98.03%
    KU-60019 是一种 ATM激酶特异性的抑制剂,IC50 为 6.3 nM。
  • HY-100016
    AZD0156Inhibitor 99.60%
    AZD0156是可口服,高效,选择性的 ATM抑制剂,IC50 为0.58 nM。
  • HY-109566
    AZD1390Inhibitor 99.81%
    AZD1390 是一种 ATM 抑制剂。
  • HY-15557
    AZ20Inhibitor 99.84%
    AZ20 是一种有效的,选择性的 ATR抑制剂,IC50 值为 5 nM;同时可抑制 mTOR活性,IC50 值为 38 nM。
  • HY-101566A
    BAY-1895344 hydrochlorideInhibitor 99.04%
    BAY-1895344 hydrochloride 是一种有效、可口服、选择性的 ATR抑制剂,IC50 值为 7 nM。具有抗肿瘤活性。
  • HY-11002
    CP-466722Inhibitor 98.40%
    CP-466722 是一种可逆的 ATM抑制剂,IC50 值为 4.1 μM,但对 PI3K,PIKK 家族蛋白没有作用。
  • HY-15520
    CGK733Inhibitor 99.93%
    CGK733 是一种有效的 ATM/ATR 抑制剂,用于癌症研究。
  • HY-15521
    ETP-46464Inhibitor 99.13%
    ETP-46464 是一种有效的 mTORATR抑制剂,IC50 分别为 0.6 和 14 nM。
  • HY-112305
    AZ32Inhibitor 99.98%
    AZ32 是一种口服可利用的,可穿透血脑屏障的 ATM抑制剂,IC50<6.2 nM。在细胞中抑制 ATM,IC50 为 0.31 μM。
  • HY-18650
    KU 59403Inhibitor
    KU 59403 是 ATM的一个有效抑制剂,其IC50 值为 3 nM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.