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  1. GPCR/G Protein
  2. Adenylate Cyclase

Adenylate Cyclase

cAMP is produced by adenylatecyclase (AC), a 12-transmembrane-spanning enzyme that catalyzes the conversion of ATP to 3′,5′-cAMP and pyrophosphate.

In neuronal and neuroendocrine cells, a variety of ligands, such as neurotransmitters and hormones, signal via activation of G protein coupled receptors (GPCRs) coupled to GSα. These receptors activate adenylatecyclases (ACs), the family of enzymes that generate cAMP.

cAMP is synthesized by adenylatecyclases (ACs) and degraded by phosphodiesterases (PDEs). Local cAMP signaling is achieved by targeting of signaling components to subcellular compartments and assembly of signaling complexes. Primary cilia also host several cAMP-signaling components: the somatostatin 3 receptor (SSTR3), various adenylatecyclases (AC3, AC4, AC6, AC8), PKA, and Epac2 (exchange protein directly activated by cAMP).

Adenylate Cyclase 相关产品 (7):

Cat. No.Product NameEffectPurity
  • HY-15371
    ForskolinActivator 98.52%
    Forskolin 是一种有效的 腺苷酸环化酶 激活剂,结合到 I 型腺苷酸环化酶 IC50 为 41 nM,激活 I 型腺苷酸环化酶 EC50 为 0.5 μM。
  • HY-100396
    SQ22536Inhibitor 98.43%
    SQ22536 是一种有效的腺苷酸环化酶 (AC) 抑制剂。
  • HY-P0252
    α-Melanocyte-Stimulating Hormone (MSH), amideActivator 98.55%
    α-Melanocyte-Stimulating Hormone (MSH), amide 刺激黑皮质素1受体,导致腺苷酸环化酶 (adenylyl cyclase) 活化。
  • HY-101279
    ST034307Inhibitor 98.11%
    ST034307 是一种有效的,选择性的 adenylyl cyclase 1抑制剂,IC50 值为 2.3 μM。
  • HY-101862
    CB-7921220Inhibitor >98.0%
    CB-7921220是腺苷酸环化酶 (adenylate cyclase) 的抑制剂。
  • HY-100524
    LRE1Inhibitor
    LRE1是可溶性腺苷酸环化酶的特异性和变构抑制剂。
  • HY-P1495
    Small Cardioactive Peptide B SCPBActivator
    Small Cardioactive Peptide B (SCPB) 是一种神经活性肽,刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性,EC50 分别为 0.1 和 1.0 μM。
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