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  1. GPCR/G Protein
  2. Adrenergic Receptor

Adrenergic Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

Adrenergic Receptor 相关产品 (182):

Cat. No.Product NameEffectPurity
  • HY-B0468
    Isoprenaline hydrochlorideAgonist >99.0%
    Isoprenaline hydrochloride是一种非选择性的β-肾上腺素能受体激动剂,具有有效的外周血管扩张剂,支气管扩张剂和心脏刺激活性。
  • HY-13715B
    Norepinephrine bitartrate monohydrateAgonist 99.75%
    Norepinephrine bitartrate monohydrate 是β1-选择性的肾上腺素能受体激动剂,EC50 为 5.37 μM。
  • HY-B0573
    Propranolol hydrochlorideAntagonist 99.92%
    Propranolol hydrochloride是一种非选择性β-肾上腺素能受体(βAR)拮抗剂,IC50 值为12 nM。
  • HY-13951
    ICI 118,551 hydrochlorideAntagonist 98.50%
    ICI 118,551 hydrochloride 是一种高度选择性的 β2肾上腺素能受体 拮抗剂,结合β2,β1 和 β3肾上腺素能受体的Ki 值分别为 0.7,49.5 和 611 nM。
  • HY-B0471
    (R)-(-)-Phenylephrine hydrochlorideAgonist 98.10%
    (R)-(-)-Phenylephrine hydrochloride是一种选择性的α1-肾上腺素能受体激动剂,对α1D,α1B和α1A受体的pKis 分为5.86,4.87和4.70。
  • HY-19436
    SolabegronAgonist
    Solabegron (GW 427353) 是 β3 肾上腺素能受体 (β3-AR) 的选择性激动剂, 在中国仓鼠卵巢细胞中测得的 EC50 值为22 nM。目前正在被用于开发治疗膀胱过度活跃和肠易激综合征。
  • HY-N0761
    3-Hydroxy-4-methoxycinnamic acidInhibitor
    3-Hydroxy-4-methoxycinnamic acid (Isoferulic acid) 是具有抗糖尿病活性的肉桂酸衍生物。3-Hydroxy-4-methoxycinnamic acid 结合并激活 α1-肾上腺素能受体 (IC50=1.4 μM),增强 β-内啡肽的分泌 (EC50=52.2 nM) 并增加体外葡萄糖的使用。
  • HY-16736A
    Centanafadine hydrochlorideInhibitor
    Centanafadine (hydrochloride) 是去甲肾上腺素 (NE)/多巴胺(DA)转运的双抑制剂,还能抑制5-羟色胺(serotonin) 转运体,其对人 NE,DA 和5-羟色胺转运体的IC50 值分别为6 nM,38 nM 和 83 nM。
  • HY-B0447B
    L-EpinephrineAgonist >99.0%
    L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergicβ-adrenergic受体激动剂。
  • HY-14773
    MirabegronAgonist 99.08%
    Mirabegron 是一种选择性的肾上腺素受体 (β3-adrenoceptor) 激动剂,EC50 为 22.4 nM。
  • HY-N0127
    Yohimbine HydrochlorideAntagonist 99.85%
    Yohimbine hydrochloride 是α-2肾上腺素能受体抑制剂,阻断突触前或突触后的α-2肾上腺素能受体,引起去甲肾上腺素和多巴胺的释放。
  • HY-B1614
    Clenbuterol hydrochlorideAgonist 99.23%
    Clenbuterol hydrochloride (NAB-365 hydrochloride) 是 β2 adrenergic受体激动剂。它是一种强效的支气管扩张剂,具有脂肪燃烧性能。
  • HY-B0162A
    Ivabradine hydrochlorideInhibitor 98.39%
    Ivabradine是可口服的,超极化激活的环核苷酸门控离子通道 (HCN) 通道阻滞剂。
  • HY-B0006
    CarvedilolInhibitor 99.93%
    Carvedilol(BM14190)是非选择性β和α1阻断剂,能抑制LDL的氧化,IC50为3.8 μM。
  • HY-B0193A
    Prazosin hydrochlorideAntagonist 99.73%
    Prazosin盐酸盐是α肾上腺素阻断剂,可作用于高血压、焦虑和恐慌症等。
  • HY-12987
    PimozideAntagonist 99.88%
    Pimozide 是 dopamine receptor 的拮抗剂,对 dopamine D2,D3 和 D1 受体的 Ki 值分别为 1.4 nM,2.5 nM 和 588 nM,同时对 α1-adrenoceptor也有较高亲和性,Ki 值为 39 nM;Pimozide 也是 STAT3STAT5 的抑制剂。
  • HY-B0362A
    Phentolamine mesylateAntagonist 99.83%
    Phentolamine mesylate是竞争性,可逆的 α-肾上腺素能受体拮抗剂,IC50 在5和30 nM之间。
  • HY-B0437
    Sotalol hydrochlorideAntagonist 99.77%
    Sotalol盐酸盐是肾上腺素受体拮抗剂,可作用于威胁生命的心律失常。
  • HY-17498
    AtenololAntagonist >98.0%
    Atenolol是选择性β1肾上腺素受体拮抗剂。
  • HY-B0443A
    Xylazine hydrochlorideAgonist 99.90%
    Xylazine盐酸盐是α2肾上腺素受体激动剂。
Isoform Specific Products

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