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  1. Metabolic Enzyme/Protease
  2. Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetases (AARSs) are ubiquitous and evolutionarily conserved enzymes that catalyze the highly specific acylation of amino acids to cognate tRNAs. Aminoacyl-tRNA Synthetases are essential for accurate decoding of the triplet genetic code and for sustenance of all domains of life, including bacteria, archaea, and eukarya.

Aminoacyl-tRNA Synthetases also perform critical cellular activities unrelated to their primary function in aminoacylation. These noncanonical activities include regulation of gene transcription, mRNA translational control, angiogenesis, apoptosis, amino acid sensing, and cell signaling.

Aminoacyl-tRNA Synthetase 相关产品 (9):

Cat. No.Product NameEffectPurity
  • HY-108900
    Leu-AMSInhibitor 99.14%
    Leu-AMS 是亮氨酰-tRNA 合成酶 (LRS) 的有效抑制剂,其 IC50 值为 22.34 nM 且能够抑制细菌的生长。
  • HY-108939
    Aminoacyl tRNA synthetase-IN-1Inhibitor 99.61%
    Aminoacyl tRNA synthetase-IN-1 是细菌中氨酰基 tRNA 合成酶 (aaRS) 的抑制剂。
  • HY-112862
    Arg-AMSInhibitor 99.80%
    Arg-AMS 是精氨酸 tRNA 合成酶 (arginyl tRNA synthetase) 的有效抑制剂,能够和非核糖体多肽合成酶的 A 结构域紧密结合。
  • HY-112860
    Asp-AMSInhibitor >98.0%
    Asp-AMS是天冬氨酸腺苷酸的一个类似物,是 aspartyl-tRNA 合成酶 (aspartyl-tRNA synthetase)的一个抑制剂,也是线粒体酶(mitochondrial enzyme) 的强效竞争性抑制剂。
  • HY-112861A
    Gln-AMS TFAInhibitor 99.50%
    Gln-AMS (TFA) 是Ia类型的氨酰基-tRNA合成酶 (AARS)抑制剂。 Gln-AMS抑制谷氨酰胺酰-tRNA合成酶Ki 值为1.32 µM。
  • HY-126130
    LysRs-IN-2Inhibitor
    LysRs-IN-2 是一种赖氨酸 tRNA 合成酶抑制剂,其对恶性疟原虫 KRS (PfKRS) 和小隐孢子虫 KRS (CpKRS) 的 IC50 值分别为 0.015 μM、0.13 μM。
  • HY-108900A
    Leu-AMS R enantiomer
    Leu-AMS R enantiomer 是 Leu-AMS 的 R 对映体。 Leu-AMS 是亮氨酰-tRNA 合成酶 (LRS) 的有效抑制剂并抑制细菌的生长。
  • HY-112861
    Gln-AMSInhibitor
    Gln-AMS 是一种氨基酰基-tRNA 合成酶 (AARS) 抑制剂,与非核糖体多肽合成酶 (NRPS) A 结构域结合。
  • HY-108940
    GlyRS-IN-1Inhibitor
    GlyRS-IN-1 是甘氨酰 tRNA 合酶 (GlyRS) 的抑制剂来自专利 WO 2017066459 A1。GlyRS-IN-1 也可以抑制细菌的生长。
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