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  1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) 相关产品 (38):

Cat. No.Product NameEffectPurity
  • HY-12403
    Angiotensin 1-7Inhibitor 99.61%
    Angiotensin (1-7) 抑制纯化的犬血管紧张素转换酶 (ACE) 活性,IC50 为 0.65 μM。
  • HY-B0368
    CaptoprilInhibitor 98.05%
    Captopril (SQ-14534) 是血管紧张素转化酶(ACE)抑制剂。
  • HY-B0093A
    Benazepril hydrochlorideInhibitor 99.85%
    Benazepril盐酸盐是血管紧张素转化酶(ACE)抑制剂,可作用于高血压。
  • HY-B0331A
    Enalapril maleateInhibitor 99.96%
    Enalapril (maleate) (MK-421 (maleate)) 是 Enalapril 的活性代谢物,是血管紧张素转化酶(ACE)抑制剂。
  • HY-N2021A
    Phosphoramidon DisodiumInhibitor >98.0%
    Phosphoramidon disodium 是金属蛋白酶 ( metalloprotease ) 抑制剂 。抑制内皮素转化酶 ( ECE ) ,中性肽内切酶 ( NEP ) 和血管紧张素转换酶 ( ACE ) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
  • HY-W009732
    Sinapinic acidInhibitor 99.61%
    Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物,为 HDAC的抑制剂,IC50 值 2.27 mM,对 ACE-I 的活性也有抑制作用。Sinapinic acid 具有有效的抗肿瘤活性,诱导肿瘤细胞凋亡。Sinapinic acid 具有抗氧化
  • HY-114424
    H-Ile-Pro-Pro-OHInhibitor
    H-Ile-Pro-Pro-OH 是一种乳源三肽,抑制血管紧张素转换酶 (ACE) ,IC50 为 5 μM。具有抗高血压效果。
  • HY-19414
    MLN-4760Inhibitor
    MLN-4760 是一种有效、选择性的人 ACE2抑制剂,IC50 值为 0.44 nM,对其选择性是对其他相关蛋白的 5000 多倍,包括人睾丸 ACE (IC50,>100 μM) 和牛 carboxypeptidase A (IC50,27 μM)。
  • HY-B0130A
    Perindopril erbumineInhibitor 99.33%
    Perindopril是长效血管紧张素转换酶(ACE)抑制剂。
  • HY-18206A
    Lisinopril dihydrateInhibitor >98.0%
    Lisinopri (dihydrate) (lMK-521 (dihydrate)) 是血管紧张素转化酶抑制剂,可作用于高血压,充血性心力衰竭和心脏病等。
  • HY-B0382
    Fosinopril sodiumInhibitor >98.0%
    Fosinopril钠是血管紧张素转换酶(ACE)抑制剂的原药,可作用于高血压和慢性心力衰竭。
  • HY-B0592
    TrandolaprilInhibitor 98.01%
    Trandolapril(RU44570)是ACE抑制剂,可作用于高血压。
  • HY-B0477
    Quinapril hydrochlorideInhibitor 99.10%
    Quinapril (hydrochloride) (CI-906) 是血管紧张素转化酶 (ACE) 抑制剂的原药。
  • HY-B0279
    RamiprilInhibitor 99.81%
    Ramipril (HOE-498) 是ACE抑制剂,IC50为5 nM。
  • HY-18208
    OmapatrilatInhibitor
    Omapatrilat是金属蛋白酶ACENEP的双重抑制剂,Ki值分别为0.64和0.45 nM。
  • HY-B0231
    Enalaprilat dihydrateInhibitor >99.0%
    Enalaprilat (dihydrate) (MK-422) 是血管紧张素转化酶 (ACE) 抑制剂,IC50 为 1.94 nM。
  • HY-B0384
    Temocapril hydrochlorideInhibitor 99.52%
    Temocapril盐酸盐是长效血管紧张素转换酶(ACE)抑制剂,可作用于高血压。
  • HY-B1451
    Imidapril hydrochlorideInhibitor 99.95%
    Imidapril盐酸盐是血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。
  • HY-A0043A
    Cilazapril monohydrateInhibitor 98.63%
    Cilazapril一水合物是血管紧张素转化酶抑制剂,可作用于高血压和充血性心力衰竭。
  • HY-P0318
    Hemorphin-7Inhibitor 99.65%
    Hemorphin-7 是一种血啡肽 (hemorphin),是来源于血红蛋白β链的一种内源性阿片类物质。Hemorphin 能够活化阿片类受体 (opioid receptor) 以及抑制血管紧张素转化酶 (angiotensin-converting enzyme),具有抗伤害、抗高血压的作用。
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