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  1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase

Aurora Kinase

Aurora kinases are serine/threonine kinases that are essential for cell proliferation. Aurora kinase helps the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. Three Aurora kinases have been identified in mammalian cells to date, Aurora A, Aurora B, Aurora C. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39 to 129 residues in length, a protein kinase domain and a short C-terminal domain containing 15 to 20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein-protein interactions.

Aurora Kinase Isoform Specific Products:

  • Aurora A

  • Aurora B

  • Aurora C

Aurora Kinase 相关产品 (36):

Cat. No.Product NameEffectPurity
  • HY-10971
    AlisertibInhibitor 99.43%
    Alisertib (MLN 8237)是选择性的 Aurora A激酶抑制剂,IC50为1.2 nM。
  • HY-10161
    TozasertibInhibitor 99.85%
    Tozasertib 是 Aurora A/B/C 激酶抑制剂,Ki 值分别为 0.6,18,4.6 nM。
  • HY-50514
    AT9283Inhibitor 99.13%
    AT9283是一种多靶点激酶抑制剂,有效抑制极光激酶A/BJAK2/3(IC50=1.2 nM, 1.1 nM)。
  • HY-10126
    Barasertib-HQPAInhibitor 99.64%
    AZD1152-HQPA是一种高度选择性的极光激酶B抑制剂,在非细胞试验中IC50 值为0.37 nM。AZD1152-HQPA对Aurora B 的选择性是Aurora A的3700倍。
  • HY-10179
    DanusertibInhibitor 99.44%
    Danusertib 是一种极光激酶 (aurora kinase) 抑制剂,能够抑制 Aurora A,Aurora B 和 Aurora C 的活性,IC50 值分别为 13,79 和 61 nM。
  • HY-114258
    LY3295668Inhibitor 98.00%
    LY3295668 是高度特异性的激光激酶 A (AurA) 的抑制剂,其对 AurA 和 AurB 的Ki 值分别为 0.8 nM 和 1038 nM。
  • HY-111506
    Aurora inhibitor 1Inhibitor
    Aurora inhibitor 1 是一种有效的 Aurora抑制剂,抑制Aurora AAurora B激酶的IC50 分别 ≤4 nM 和 ≤13 nM。
  • HY-10127
    AZD1152Inhibitor 98.95%
    AZD1152 是 Barasertib-hQPA 的前体药物,是高度选择性的 Aurora B抑制剂,IC50 值为 0.37 nM。
  • HY-70044
    GSK-1070916Inhibitor 99.55%
    GSK-1070916是有效,选择性,ATP竞争型的极光激酶B/C (aurora B/C) 抑制剂,Ki 值分别为0.38和1.5 nM。
  • HY-14711
    ReversineInhibitor 99.25%
    Reversine 是一种ATP-竞争性的 Aurora kinase抑制剂,作用于Aurora AAurora BAurora CIC50 分别为 400,500 和 400 nM。
  • HY-10180
    MLN8054Inhibitor >98.0%
    MLN8054是高效,选择性,有口服活性的极光激酶 (aurora A) 抑制剂,IC50 值为4 nM。
  • HY-12054
    HesperadinInhibitor 98.48%
    Hesperadin是ATP竞争型的极光激酶 (aurora B) 抑制剂,IC50值为250 nM。
  • HY-10339
    KW-2449Inhibitor 99.85%
    KW-2449是多靶点激酶抑制剂,对FLT3ABLABLT315IAurora kinaseIC50 值分别为6.6,14,4 和 48 nM.
  • HY-10329
    JNJ-7706621Inhibitor 98.80%
    JNJ-7706621 是一种有效的 aurora kinase抑制剂,同时能有效抑制CDK1CDK2,对 CDK1,CDK2,Aurora-A 和 Aurora-B 的 IC50 值分别为 9,3,11 和 15 nM。
  • HY-14574
    PF-03814735Inhibitor 99.77%
    PF-03814735是有效,有口服性,可逆的极光激酶A和B (aurora A/B) 的抑制剂,IC50值分别为0.8和5 nM。
  • HY-15767
    TAK-632Inhibitor 99.13%
    TAK-632 是一种有效的 pan-RAF抑制剂,作用于CRAFBRAFV600EBRAFWTIC50 分别为 1.4,2.4 和 8.3 nM。
  • HY-13253
    AMG 900Inhibitor 98.19%
    AMG 900 是一种有效的选择性的 pan-Aurora激酶抑制剂,作用于Aurora ABCIC50 分别为 5 nM,4 nM 和 1 nM。
  • HY-12201
    TAK-901Inhibitor 99.80%
    TAK-901是多靶点的的极光激酶 (aurora)抑制剂,对极光激酶A和B的IC50 值分别为21 和15 nM。
  • HY-13252
    MK-5108Inhibitor 98.62%
    MK-5108是高效和特异性的极光激酶A抑制剂,IC50 值为0.064 nM。
  • HY-12003
    SNS-314Inhibitor 99.81%
    SNS-314有效,选择性的极光激酶 (aurora) 抑制剂,对极光激酶A,B,C的IC50 值分别为9,31 和6 nM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.