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  1. Membrane Transporter/Ion Channel
  2. BCRP

BCRP

BCRP(breast cancer resistant protein) is an ATP-binding cassette (ABC) transporter, which together with two other ABC efflux drug pumps, namely P-glycoprotein (P-gp, ABCB1) and multidrug resistance-related protein 1 (MRP1, ABCC1) is the most important multidrug resistance protein found in eukaryotic cells including cells in the testis.

Breast cancer resistance protein (BCRP/ABCG2) is known to localize at the blood-brain barrier (BBB) and can significantly restrict xenobiotic permeability in the brain. The objective of this study is to investigate the regulation of BCRP functional expression by peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor primarily involved in lipid metabolism, in a cerebral microvascular endothelial cell culture system (hCMEC/D3), representative of human BBB.

BCRP 相关产品 (9):

Cat. No.Product NameEffectPurity
  • HY-10010
    Ko 143Inhibitor 99.79%
    Ko 143是有效且选择性的ATP结合盒亚家族G成员2 (ABCG2) 抑制剂。
  • HY-50879
    ElacridarInhibitor 98.47%
    Elacridar 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。
  • HY-N2143
    Fumitremorgin CInhibitor 99.63%
    Fumitremorgin C是有效,选择性的ABCG2/BRCP抑制剂。
  • HY-19753
    KS176Inhibitor 99.21%
    KS176是一种选择性的高活性乳腺癌耐药蛋白多药转运通道 (BCRP) 抑制剂(在Pheo A和Hoechst检测中IC50值分别为0.59和1.39 μM)。对P-gp和MRP1没有抑制活性。
  • HY-12757
    YHO-13177Inhibitor 98.40%
    YHO-13177是高活性乳腺癌耐药蛋白多药转运通道(BCRP)抑制剂,可增强SN-38活性且对P-gp无作用。
  • HY-12758
    YHO-13351Inhibitor
    YHO-13351是YHO-13177的水溶性前体药物,YHO-13177是腺癌耐药蛋白多药转运通道(BCRP)高效特异性抑制剂。
  • HY-12758A
    YHO-13351 free baseInhibitor 98.10%
    YHO-13351 (free base) 是YHO-13177的水溶性前体药物,YHO-13177是腺癌耐药蛋白多药转运通道(BCRP)高效特异性抑制剂。
  • HY-100390
    BCRP-IN-1Inhibitor 98.13%
    BCRP-IN-1 是一种乳腺癌抗性蛋白 (BCRP) 抑制剂,抑制 BCRP 外排转运蛋白上,IC50 为 0.6 μM。
  • HY-106004
    ZamicastatInhibitor
    Zamicastat (BIA 5-1058) 是 多巴胺 β-羟化酶 (DBH)的抑制剂,可通过血脑屏障引起中枢和周边效应。Zamicastat 也是一种浓度依赖性的双重 P-gpBCRP抑制剂,IC50 值分别为 73.8 μM 和 17.0 μM。具有降血压作用。
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