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  1. Membrane Transporter/Ion Channel
  2. CRM1

CRM1

Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (eg, p53 and nucleophosmin) whose function is altered in cancer because of increased expression and overactive transport. Blocking CRM1-mediated nuclear export of such proteins is a novel therapeutic strategy to restore tumor suppressor function. Orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of this protein have been recently developed.

CRM1 is the sole exporter of many tumor-suppressor proteins (TSPs), and functions as a proto-oncogene by transporting these tumor suppressors from the nucleus, where they are active, to the cytoplasm, where their activity is abrogated.

CRM1 相关产品 (7):

Cat. No.Product NameEffectPurity
  • HY-17536
    SelinexorInhibitor 99.82%
    Selinexor (KPT-330),是 KPT-185 的类似物,是一种口服活性的,CRM1 的选择性抑制剂。
  • HY-100423
    EltanexorInhibitor 99.68%
    KPT-8602 是一个第二代的 exportin-1抑制剂。
  • HY-100423A
    Eltanexor Z-isomerInhibitor
    KPT-8602 Z-isomer是活性较弱的KPT-8602异构体。KPT-8602为高效的CRM1抑制剂。
  • HY-17539
    KPT-276 99.05%
    KPT-276, analog of KPT-185, is an orally bioavailable selective inhibitors of nuclear export (SINE) that irreversibly bind to CRM1 and block the function of CRM1.
  • HY-15611
    KPT-185 98.24%
    KPT-185 is an orally bioavailable selective inhibitor of CRM1 amd displayes potent antiproliferative properties at submicromolar concentrations (IC50 values:100-500nM), induced apoptosis (average 5-fold increase), cell-cycle arrest, and myeloid differenti
  • HY-16909
    Leptomycin BInhibitor >98.0%
    Leptomycin B (CI 940; LMB) 是一种蛋白出核转运抑制剂。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1 失活。 Leptomycin B 是一种有效的抗真菌抗生素,可阻断真核细胞周期。
  • HY-15970
    VerdinexorInhibitor 99.97%
    Verdinexor(KPT-335)是新型口服活性出核抑制剂(SINE),能有效抑制犬肿瘤细胞系出核蛋白Exportin 1(XPO1/CRM1),也能降低流感病毒的复制水平。
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