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  1. Metabolic Enzyme/Protease
  2. Carbonic Anhydrase

Carbonic Anhydrase

Carbonic anhydrase is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2+H2O<-->HCO3-+H+. The enzyme is the target for drugs, such as Acetazolamide, Methazolamide, and Dichlorphenamide, for the treatment of glaucoma. There are three evolutionarily unrelated CA families, designated alpha, beta, and gamma. All known CAs from the animal kingdom are of the alpha type. There are seven mammalian CA isozymes with different tissue distributions and intracellular locations, CA I-VII.

Carbonic anhydrase is one of the core enzyme in organism, which involves in osmoregulation, ionic regulation, acid-base regulation and other physiological and biochemical process.

Carbonic Anhydrase 相关产品 (15):

Cat. No.Product NameEffectPurity
  • HY-B0782
    AcetazolamideInhibitor 99.87%
    Acetazolamide 是一种碳酸酐酶 (carbonic anhydraseCA)IX抑制剂,抑制hCA IXIC50 为 30 nM。利尿剂。
  • HY-B0553
    MethazolamideInhibitor
    Methazolamide是碳酸酐酶抑制剂,可作用于青光眼。
  • HY-B0588
    BrinzolamideInhibitor 99.78%
    Brinzolamide(AL 4862)是碳酸酐酶(carbonic anhydrase)II抑制剂,IC50为3.19 nM。
  • HY-B0109A
    Dorzolamide hydrochlorideInhibitor 99.47%
    Dorzolamide(L671152; MK507)盐酸盐是碳酸酐酶(CA)抑制剂,可作用于青光眼。
  • HY-B0397
    DichlorphenamideInhibitor >98.0%
    Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。
  • HY-13650
    IndisulamInhibitor 98.92%
    Indisulam (E 7070) 是一种 碳酸酐酶抑制剂,也是细胞周期G1期的靶向化合物。通过抑制细胞周期蛋白依赖型激酶 2 (CDK2) 和周期蛋白 E (cyclin E) 的激活,导致G1/S转化被阻滞。在人结肠癌和肺癌细胞中显示了抗肿瘤活性。
  • HY-B1424
    BenzthiazideInhibitor >99.0%
    Benzthiazide 是一种长效的利尿剂和抗高血压剂。Benzthiazide 为碳酸酐酶 9 (carbonic anhydrase 9 (CA9)) 的抑制剂,对 CA9,CA2 和 CA1 的 Ki 值分别为 8.0,8.8 和 10 nM。Benzthiazide 能够抑制肿瘤细胞增殖。
  • HY-B1480
    EthoxzolamideInhibitor 98.78%
    Ethoxzolamide 是 carbonic anhydrase的抑制剂,其Ki 值为 1 nM。
  • HY-108316
    SultiameInhibitor 99.11%
    Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。
  • HY-B0782S
    Acetazolamide D3Inhibitor
    Acetazolamide D3是Acetazolamide氘代化合物标准品。
  • HY-13513
    U-104Inhibitor 99.55%
    U-104是碳酸酐酶(Carbonic anhydrase)CA IX和CA XII高效抑制剂,Ki值分别为45.1nM和4.5nM。
  • HY-B0109
    DorzolamideInhibitor
    Dorzolamide(L671152; MK507)是碳酸酐酶(CA)抑制剂,可作用于青光眼。
  • HY-B0483
    TioxoloneInhibitor >98.0%
    Tioxolone是金属酶碳酸酐酶(metalloenzyme carbonic anhydrase)I抑制剂,有抗痤疮活性。
  • HY-N0085
    DimethylfraxetinInhibitor 99.97%
    Dimethylfraxetin 是一种 Carbonic anhydrase抑制剂,其Ki 值为 0.0097 μM。
  • HY-B2147
    2-AminobenzenesulfonamideInhibitor 99.88%
    2-Aminobenzenesulfonamide 是碳酸酐酶 IX (carbonic anhydrase IX) 的抑制剂。
Isoform Specific Products

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