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  1. Protein Tyrosine Kinase/RTK
  2. DYRK

DYRK

Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

DYRK 相关产品 (7):

Cat. No.Product NameEffectPurity
  • HY-N0737A
    HarmineInhibitor 99.78%
    Harmine是一种具有抗癌和抗炎活性的天然双特异性酪氨酸磷酸化调节激酶 ((DYRK)) 抑制剂。
  • HY-12277
    AZ191Inhibitor 99.63%
    AZ191是DYRK1B高效选择性抑制剂,IC50值17nM。
  • HY-12838
    Mirk-IN-1Inhibitor 99.53%
    Mirk-IN-1(Dyrk1B/A-IN-1)是Dyrk1B和Dyrk1A高效选择性抑制剂,IC50值分别为68和22nM。
  • HY-15838
    ID-8Inhibitor >98.0%
    ID-8是DYRK抑制剂,长时间培养可维持胚胎干细胞的自我更新。
  • HY-U00439A
    Protein kinase inhibitors 1 hydrochlorideInhibitor >98.0%
    Protein kinase inhibitors 1 hydrochloride 是一种有效的 HIPK2 抑制剂,对 HIPK1 和 HIPK2 的 IC50 值分别为 136 和 74 nM,对 HIPK2 的 Kd 值为 9.5 nM。
  • HY-U00439
    Protein kinase inhibitors 1Inhibitor >99.0%
    Protein kinase inhibitors 1 是一个新型的 HIPK2抑制剂,其IC50 值为 74 nM, Kd 值为 9.5 nM。
  • HY-111380
    EHT 5372Inhibitor
    EHT 5372 是双特异性酪氨酸磷酸化调节酶 (DYRK)的强效抑制剂,其IC50 值分别为 0.22,0.28 nM。
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