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  1. Protein Tyrosine Kinase/RTK
  2. FAK

FAK

FAK (Focal Adhesion Kinase or PTK2) is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes. It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility. FAK is found concentrated in the focal adhesions that form among cells attaching to extracellular matrix constituents. FAK is a member of the FAK subfamily of protein tyrosine kinases that included PYK2 but lacks significant sequence similarity to kinases from other subfamilies. With the exception of certain types of blood cells, most cells express FAK. FAK tyrosine kinase activity can be activated, which plays a key important early step in cell migration. FAK activity elicits intracellular signal transduction pathways that promote the turn-over of cell contacts with the extracellular matrix, promoting cell migration.

FAK 相关产品 (14):

Cat. No.Product NameEffectPurity
  • HY-13917
    PND-1186Inhibitor 99.71%
    PND-1186 是有效可逆的 FAK抑制剂,细胞试验中的IC50 为1.5 nM。
  • HY-12289
    DefactinibInhibitor 99.74%
    Defactinib 是一种新型 FAK 抑制剂,抑制 FAK 在 Tyr397 位点磷酸化,这种作用具有时间和剂量依赖性。
  • HY-10461
    PF-573228Inhibitor 98.72%
    PF-573228是有效的和选择性的FAK抑制剂,对FAK纯化重组催化片段的IC50值为4 nM。
  • HY-12444
    Y15Inhibitor >98.0%
    Y15是一种有效,特异性的粘着斑激酶抑制剂 (FAK),可抑制其自身磷酸化活性,降低癌细胞的活力,阻断肿瘤生长。
  • HY-10459
    PF-562271Inhibitor 99.36%
    PF-562271 是有效,可逆,ATP竞争性的 FAKPyk2激酶抑制剂,IC50 分别为 1.5 和 13 nM。
  • HY-111546
    BI-3663Inhibitor
    BI-3663 是一种高度选择性的 PTK2/FAK PROTAC,具有 VHL 和 E3 连接酶配体,能够降解 PTK2,IC50 值为 18 nM。具有抗肿瘤活性。
  • HY-100498
    GSK2256098Inhibitor 99.35%
    GSK2256098 是一种选择性 FAK 激酶抑制剂,可抑制胰腺癌细胞的生长和存活。
  • HY-15841
    CEP-37440Inhibitor 99.87%
    CEP-37440是新型FAK和ALK双重抑制剂,IC50分别为2.3 nM和120 nM。
  • HY-12289A
    Defactinib hydrochlorideInhibitor 99.11%
    Defactinib盐酸盐(VS-6063; PF-04554878)是一高效FAK激酶磷酸化抑制剂,能通过AKY依赖性通路客服YB1介导的paclitaxel耐受。
  • HY-10460
    PF-431396Inhibitor 99.15%
    PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.
  • HY-13203
    NVP-TAE 226Inhibitor 98.98%
    NVP-TAE 226 是一种双重酪氨酸激酶抑制剂,作用于 FAKIGF-IRIC50 分别为 5.5 nM 和 0.14 μM。
  • HY-10458
    PF-562271 besylateInhibitor 98.31%
    PF-562271 besylate 是有效,可逆,ATP竞争性的 FAKPyk2激酶抑制剂,IC50 分别为 1.5 和 13 nM。
  • HY-19376
    NAMI-AInhibitor >98.0%
    NAMI-A 是一种钌基试剂,其特征在于对肿瘤转移的选择性活性,抑制粘附和迁移。
  • HY-B1305
    Chloropyramine hydrochlorideInhibitor 99.30%
    Chloropyramine hydrochloride 是一种组胺受体 H1 (histamine receptor H1) 拮抗剂,它也能抑制 VEGFR-3FAK 的生化功能。
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