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  1. Apoptosis
  2. Ferroptosis

Ferroptosis

Ferroptosis is a non-apoptotic form of regulated cell death. It is distinct from other regulated cell death phenotypes, such as apoptosis and necroptosis. Ferroptosis is characterized by extensive lipid peroxidation, which can be suppressed by iron chelators or lipophilic antioxidants. Mechanistically, Ferroptosis inducers are divided into two classes: (1) inhibitors of cystine import via system xc (e.g., Erastin), which subsequently causes depletion of glutathione (GSH), and (2) covalent inhibitors (e.g., (1S, 3R)-RSL3) of glutathione peroxidase 4 (GPX4). Since GPX4 reduces lipid hydroperoxides using GSH as a co-substrate, both compound classes ultimately result in loss of GPX4 activity, followed by elevated levels of lipid reactive oxygen species (ROS) and consequent cell death.

Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Misregulated Ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity.

Ferroptosis 相关产品 (8):

Cat. No.Product NameEffectPurity
  • HY-15763
    ErastinActivator 99.42%
    Erastin是铁诱导的细胞死亡 (ferroptosis) 激活剂。
  • HY-100579
    Ferrostatin-1Inhibitor 99.72%
    Ferrostatin-1 是 ferroptosis的强效抑制剂,其EC50 值为 60 nM。
  • HY-12726
    Liproxstatin-1Inhibitor 98.38%
    Liproxstatin-1 是一种有效的 ferroptosis抑制剂,IC50 值约为 38 nM。
  • HY-100887
    Piperazine ErastinActivator 99.75%
    Piperazine erastin是erastin的类似物,其诱导铁离子依赖形式的非凋亡性细胞死亡,称为铁死亡。
  • HY-103087
    FIN56Activator 98.03%
    FIN56 是一种特异性的铁死亡诱导剂。
  • HY-112909
    UAMC-3203Inhibitor
    UAMC-3203是有效,选择性的 Ferroptosis抑制剂,IC50为12 nM。
  • HY-114481
    Imidazole ketone erastinActivator
    Imidazole ketone erastin (IKE)是一种有效的,选择性的,代谢稳定的胱氨酸-谷氨酸逆转运蛋白,system Xc-抑制剂和ferroptosis 活化剂。
  • HY-112063
    CIL56Activator 99.02%
    CIL56 是一种有效的选择性ferroptosis 诱导剂。Ferroptosis 是铁依赖性的调控细胞死亡 (RCD) 的非细胞凋亡形式。
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