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  1. GPCR/G Protein
  2. GNRH Receptor

GNRH Receptor

GNRH Receptor (Gonadotropin-releasing hormone receptor, GNRHR), also known as the luteinizing hormone releasing hormone receptor (LHRHR), is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes,breast, ovary, and prostate. GNRH Receptor is a 60 kDa G protein-coupled receptor and resides primarily in the pituitary and is responsible for eliciting the actions of LHRH after its release from the hypothalamus. Upon activation, GNRH Receptor stimulates tyrosine phosphatase and elicits the release of LH from the pituitary. Following binding of Gonadotropin releasing hormone (GNRH), GNRH Receptor associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

GNRH Receptor 相关产品 (14):

Cat. No.Product NameEffectPurity
  • HY-16168A
    DegarelixAntagonist 99.92%
    Degarelix是一种竞争性,可逆的的促性腺激素释放激素受体 (GnRHR) 拮抗剂。
  • HY-13665
    Leuprolide AcetateAgonist 99.88%
    Leuprolide acetate是一种有效的促性腺激素释放激素 (GNRH)受体激动剂,用于治疗前列腺癌,子宫内膜异位症,子宫肌瘤。
  • HY-17405
    Alarelin AcetateAgonist 99.61%
    Alarelin acetate是合成的GnRH激动剂。
  • HY-P0009A
    Cetrorelix AcetateAntagonist 98.88%
    Cetrorelix Acetate是 GnRH受体的强效拮抗剂,其IC50 值为 1.21 nM.
  • HY-13673A
    Goserelin acetateAgonist 99.96%
    Goserelin (ICI 118630)乙酸盐是GnRH激动剂。
  • HY-13534
    AbarelixAntagonist 98.11%
    Abarelix 是有效的促性腺激素释放激素 (GnRH) 拮抗剂,用于治疗前列腺癌。
  • HY-13581A
    Buserelin AcetateAgonist 99.98%
    Buserelin (INN) Acetate是一个GnRH的激动剂。
  • HY-14789
    ElagolixAntagonist 98.06%
    Elagolix是一种高度有效的, 选择性, 口服活性的, 短期的, 非肽类促性腺激素释放激素受体 (GnRH受体) 拮抗剂 (KD = 54 pM)。
  • HY-16474
    RelugolixAntagonist >98.0%
    Relugolix是一个新颖的,非肽的能够口服的GnRH拮抗剂,IC50值是0.33 nM.
  • HY-14369
    Elagolix sodiumAntagonist 99.20%
    Elagolix sodium 是一种人的 GnRH 受体 (GnRHR) 拮抗剂,其 IC50Ki 值分别为 0.25 和 3.7 nM。
  • HY-12555
    Gonadorelin acetateAgonist 99.97%
    Gonadorelin醋酸盐是一种类似于促性腺激素释放激素(GnRH)的人造蛋白。
  • HY-P0051
    LecirelinAgonist
    Lecirelin 是 GnRH 的合成类似物,可用于治疗牛卵巢滤泡囊肿。
  • HY-13673
    GoserelinAgonist
    Goserelin(ICI 118630)是注射型促性腺激素释放激素(GnRH)超激动剂。
  • HY-U00289
    opigolixAntagonist
    Opigolix 是一种促性腺激素释放激素 (GnRH) 受体拮抗剂,可用于子宫内膜异位症和风湿性关节炎等疾病的研究。
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