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  1. Cell Cycle/DNA Damage
  2. IRE1

IRE1

The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene. IRE1 is an endoplasmic reticulum (ER) transmembrane sensor that activates UPR to maintain ER and cellular function. While mammalian IRE1 promotes cell survive, it can initiate apoptosis via decay of anti-apoptotic microRNAs.

IRE1 activation is initiated by homotypic interactions of the stress-sensing lumenal domain favoring transautophosphorylation of the kinase-extension nuclease (KEN) domain on the cytoplasmic side of the ER membrane.

IRE1/XBP-1 has been shown to regulate a variety of genes in various cell types in response to ER stress, mostly related to ER function and the secretory pathway, although the target genes vary depending on the cell type and nature of the stress stimuli.

IRE1 相关产品 (13):

Cat. No.Product NameEffectPurity
  • HY-15845
    STF-083010Inhibitor >98.0%
    STF-083010 is an Ire1 inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress.
  • HY-19707
    4μ8CInhibitor 98.52%
    4μ8C (IRE1 Inhibitor III)是IRE1α的小分子抑制剂。
  • HY-19708
    KIRA6Inhibitor 98.75%
    KIRA6变构抑制IRE1α RNase激酶活性,IC50值为0.6 µM。
  • HY-17537
    APY29Inhibitor 99.54%
    APY29 是一种特异性的 IRE1α别构调节剂,能够抑制IRE1α的自主磷酸化,IC50 值为 280 nM,也可激活核糖核酸酶活性。
  • HY-19710
    MKC3946Inhibitor 99.77%
    MKC3946 是一种有效的 IRE1α 抑制剂,常用于癌症研究。
  • HY-114368
    Kira8Inhibitor
    Kira8 是一种单选择性 IRE1α抑制剂,可以变构减弱IRE1α RNase活性,IC50 为 5.9 nM。
  • HY-U00459
    GSK2850163Inhibitor >98.0%
    GSK2850163 是一个新型的肌醇需要酶-1α (IRE1α) 抑制剂,它可抑制 IRE1α 的激酶活性和 RNA 酶活性,其 IC50 值分别为 20 和 200 nM。
  • HY-104040
    MKC8866Inhibitor 98.38%
    MKC8866 是一种肌醇需要酶 (IRE-1α)抑制剂,IC50 小于 0.1 μM。
  • HY-12399
    MKC9989Inhibitor 98.61%
    MKC9989 是一种 HAA抑制剂,且能抑制IRE1αIC50 值在 0.23 μM 至 44 μM 的范围之间。
  • HY-107371
    NSC95682Inhibitor 99.87%
    NSC95682 是一个 IRE-1α抑制剂,其IC50 值为 0.08 μM,来自专利 WO 2008154484 A1, 实例 IRE-lα 抑制剂化合物 3-5。
  • HY-U00460
    3,6-DMAD hydrochlorideInhibitor >98.0%
    3,6-DMAD hydrochloride是未折叠蛋白质应答 (IRE1α-XBP1) 通路的抑制剂。
  • HY-U00459B
    GSK2850163 hydrochlorideInhibitor
    GSK2850163 hydrochloride 是一个新型的肌醇需要酶-1α (IRE1α) 抑制剂,它可抑制 IRE1α 的激酶活性和 RNA 酶活性,其 IC50 值分别为 20 和 200 nM。
  • HY-107400
    B I09Inhibitor
    B I09 是 IRE-1核糖核酸酶的一个抑制剂,其IC50 值为 1230 nM。
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