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  1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor

Insulin Receptor

Insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.

Insulin Receptor 相关产品 (15):

Cat. No.Product NameEffectPurity
  • HY-P0035
    Insulin(human)
    Insulin(human) 是一种多肽激素,其调节血液中的糖(葡萄糖)水平并且由胰岛的β细胞产生。
  • HY-10191
    LinsitinibInhibitor 99.90%
    Losmapimod是 IGF-1胰岛素受体的双重抑制剂,IC50 分别为35 和 75 nM。
  • HY-15656
    CeritinibInhibitor 99.97%
    Ceritinib (LDK378) 是有效且特异性的 ALK抑制剂,IC50 为 0.2 nM。
  • HY-P1156
    Insulin(cattle) 98.60%
    Insulin cattle 是牛胰脏中胰岛 B-细胞所分泌的一种调节糖代谢的蛋白质激素,是一种多肽。
  • HY-10200
    BMS-754807Inhibitor 99.18%
    BMS-754807 是有效、可逆的胰岛素样生长因子1受体/胰岛素受体抑制剂,其IC50 值分别为 1.8 和 1.7 nM,Ki 值均小于 2 nM;同时也抑制 Met,RON,TrkA,TrkB,AurA 和 AurB 的活性,其IC50 值分别为 6,44,7,4,9和 25 nM。
  • HY-50866
    NVP-AEW541Inhibitor 98.76%
    NVP-AEW541 是一种有效的 IGF-1R抑制剂,IC50 为 0.15 μM,也抑制 InsRIC50 为 0.14 μM。
  • HY-10262
    BMS-536924Inhibitor 98.73%
    BMS-536924是ATP竞争性IGF-1R/IR抑制剂, IC50分别为100 nM/73 nM。
  • HY-100037
    NT157Inhibitor 99.19%
    NT157是一种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 μM。
  • HY-13020
    GSK1838705AInhibitor 98.99%
    GSK1838705A是高效,可逆的 IGF-IR 和胰岛素受体 (insulin receptor) 抑制剂,IC50 值分别为2.0 和 1.6 nM。也可抑制 ALKIC50 值为0.5 nM。
  • HY-15656A
    Ceritinib dihydrochlorideInhibitor 99.86%
    Ceritinib dihydrochloride (LDK378 dihydrochloride) 是 ALK 抑制剂,IC50 为 0.2 nM,比对 IGF-1R 和 InsR 的抑制性高 40 倍和 35 倍。
  • HY-100550
    MSDC 0160 >98.0%
    MSDC 0160是一种胰岛素增敏剂,同时也调节线粒体丙酮酸载体(MPC),后者控制细胞代谢,从而影响mTOR的活化。
  • HY-112720
    AGL-2263Inhibitor
    AGL-2263 是胰岛素受体 (IR) 的一个阻断剂。
  • HY-15481
    KU14RAntagonist
    KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。
  • HY-112819
    Insulin levels modulatorModulator
    Insulin levels modulator 可用于治疗糖尿病。
  • HY-N0628
    KaempferitrinActivator
    Kaempferitrin 是一种天然黄酮苷类化合物,具有镇痛、消炎、抗糖尿病、抗肿瘤和化疗的作用,同时可激活胰岛素 (insulin) 信号传导.
Isoform Specific Products

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Please try each isoform separately.