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  1. MAPK/ERK Pathway
  2. KLF

KLF

Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. KLFs can be deregulated in multiple cancers either by loss of heterozygosity (LOH), somatic mutation or transcriptional silencing by promoter hypermethylation.

KLF family member proteins play a critical role in the growth and metastasis of numerous tumor types, at least in part by regulating the expression of cell cycle genes. Globally, KLF4 and KLF6 are considered as tumor suppressor gene, whereas KLF5 promotes cell proliferation. Family members have different transcriptional properties and can modulate each other's activity by a variety of mechanisms. Since cells can express multiple KLFs, KLF transcription factors build likely a transcriptional network to control cell proliferation. Effects of changes in KLF factors are context-dependent and can appear contradictory, considering differences in the expression profile of family members in various cells. Last, KLF variants may antagonize the function of wild type proteins.

KLF 相关产品 (2):

Cat. No.Product NameEffectPurity
  • HY-16291
    APTO-253Activator
    APTO-253 是一种 Kruppel-like factor 4诱导剂,同时可稳定Gquadruplex 结构,具有抗癌活性。
  • HY-19994
    ML264Inhibitor 99.67%
    ML264 是一种抗肿瘤剂,可有效和选择性地抑制 Krüppel 样因子 5 (KLF5) 表达。
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