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  1. Metabolic Enzyme/Protease
    NF-κB
  2. MALT1

MALT1

MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.

MALT1 相关产品 (3):

Cat. No.Product NameEffectPurity
  • HY-12276
    MI 2Inhibitor 99.56%
    MI 2 (MALT1 inhibitor) 是一种不可逆的 MALT1蛋白酶抑制剂,IC50 为 5.84 μM。
  • HY-115466
    MLT-748Inhibitor
    MLT-748 是一种 MALT1 的别构抑制剂,与 MALT1 的别构 Trp580 口袋结合,IC50 值为 5 nM。MLT-748 不可逆地与人突变型 MALT1(329-728)-W580S 和野生型 MALT1(329-728) 结合,Kd 值分别为 13 nM 和 42 nM。
  • HY-124587
    MLT-747Inhibitor
    MLT-747 是一种 MALT1 的别构抑制剂,与 MALT1 的别构 Trp580 口袋结合,IC50 值为 14 nM。
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