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  1. MAPK/ERK Pathway
  2. MAP3K

MAP3K

MAP3Ks (Mitogen-activated protein kinase kinase kinases), the top components of MAPK cascades, modulate many biological processes, such as growth, development and various environmental stresses. Based on the sequence of their kinase catalytic domain, MAP3Ks are classified into three groups: the MEKK-like, ZIK-like and Raf-like families. Raf-like MAP3Ks constitute largest MAP3K subfamily. Raf-like MAP3Ks play roles in response to biotic and abiotic stresses.

MAP3Ks often bind to both MAP4Ks and MAP2Ks in the same pathway. For example, MEKK1 (MAP3K1) binds to both the MAP4K NIK and the MAP2K MKK4, while NSY-1 (MAP3K) binds to the MAP2K SEK-1. MAP3Ks activates MAP2Ks by phosphorylation of a serine and/or threonine, and MAP2Ks activate MAPKs by dual phosphorylation of a Thr-X-Tyr motif.

MAP3K Isoform Specific Products:

  • MAP3K5/ASK1

  • MAP3K7/TAK1

MAP3K 相关产品 (9):

Cat. No.Product NameEffectPurity
  • HY-103490
    TakinibInhibitor 98.00%
    Takinib 是一种有效且有选择性的 TAK1抑制剂,其IC50 值为 9.5 nM。
  • HY-18938
    SelonsertibInhibitor 99.12%
    Selonsertib是一种凋亡信号调节激酶1 (ASK1) 抑制剂,pIC50 为8.3。
  • HY-15434
    NG25Inhibitor 99.45%
    NG25 是一种 TAK1MAP4K2的双抑制剂,IC50 值分别为 149 nM 和 21.7 nM。
  • HY-12947
    GNE-3511Inhibitor 99.98%
    GNE-3511是双亮氨酸拉链激酶 (DLK)抑制剂,Ki为0.5 nM。
  • HY-12686
    5Z-7-OxozeaenolInhibitor >99.0%
    5Z-7-Oxozeaneol 是一种天然的抗原生动物化合物,为有效的,不可逆的,选择性的 TAK1VEGF-R2抑制剂,IC50 值分别为 8 nM 和 52 nM。
  • HY-114331
    DLK-IN-1Inhibitor
    DLK-IN-1 是双亮氨酸拉链激酶 (DLK, MAP3K12)的选择性抑制剂,其Ki 值为 3 nM。DLK-IN-1 保持着良好的中枢神经系统穿透能力,并且在脑内剂量过量后依旧耐受性良好,在阿尔兹海默症动物模型中有良好的活性。
  • HY-19566
    NQDI-1Inhibitor
    NQDI-1 抑制凋亡信号调节激酶 1 (ASK1),Ki 为 500 nM,IC50 为 3 μM.
  • HY-77251
    TAK1/MAP4K2 inhibitor 1Inhibitor 99.70%
    TAK1/MAP4K2 inhibitor 1 是一种 TAK1MAP4K2的双重抑制剂,IC50 值分别为 41.1 nM 和 18.2 nM。
  • HY-100844
    GS-444217Inhibitor 99.80%
    GS-444217 是一种有效的选择性 ATP 竞争性凋亡信号调节激酶 1 (ASK1) 抑制剂,IC50 为 2.87±0.85 nM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.