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  1. PI3K/Akt/mTOR
  2. MELK

MELK

MELK (Maternal embryonic leucine zipper kinase) belongs to the CAMK serine/threonine protein kinase superfamily. Melk is a protein serine/threonine kinase that is maximally active during mitosis. It is involved in diverse functions such as cell cycle, cytokinesis, mRNA splicing and apoptosis. Expression MELK is expressed in cells of various tissue origins. MELK expression is strongly dependant on cell-cycle: MELK is undetectable in cells which have exited cell cycle. The exact function of MELK is currently unknown, however MELK was shown to be involved in cell cycle progression via the protein phosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis via its interaction with the Bcl-2 family of proapoptotic genes and apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association with NIPP1. MELK function is required for mammary tumorigenesis in vivo.

MELK 相关产品 (5):

Cat. No.Product NameEffectPurity
  • HY-15512A
    OTSSP167 hydrochlorideInhibitor 99.85%
    OTSSP167 hydrochloride 是一种高效的 MELK抑制剂,IC50 值为 0.41 nM。
  • HY-100368A
    MELK-8a hydrochlorideInhibitor 99.23%
    MELK-8a hydrochloride是一种新颖的母体胚胎亮氨酸拉链激酶(MELK)抑制剂,其IC50值为2 nM。
  • HY-12420
    JNJ-47117096 hydrochlorideInhibitor 99.40%
    JNJ-47117096 hydrochloride 是一种有效的,选择性的 MELK抑制剂,IC50 值为 23 nM;同时对 Flt3的作用较强,IC50 值为 18 nM。
  • HY-15512
    OTSSP167Inhibitor
    OTSSP167 是一种高效的 MELK抑制剂,IC50 值为 0.41 nM。
  • HY-101515
    MELK-IN-1Inhibitor
    MELK-IN-1是母体胚胎亮氨酸拉链激酶 (MELK)的有效抑制剂,IC50Ki 分别为3 nM和0.39 nM。
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