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  1. Neuronal Signaling
  2. Monoamine Oxidase

Monoamine Oxidase

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase 相关产品 (42):

Cat. No.Product NameEffectPurity
  • HY-B1496
    Tranylcypromine hemisulfateInhibitor >99.0%
    Tranylcypromine hemisulfate是一种用于治疗抑郁症的不可逆,非选择性 MAO 抑制剂。
  • HY-B1018A
    Phenelzine sulfateInhibitor 98.70%
    Phenelzine硫酸盐是一种非选择性和不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药和抗焦虑药。
  • HY-14197A
    Clorgyline hydrochlorideInhibitor 99.53%
    Clorgyline hydrochloride 是不可逆的,选择性单胺氧化酶A(MAO-A)抑制剂,结构上与Pargyline相关。
  • HY-100546A
    GSK-LSD1 DihydrochlorideInhibitor >98.0%
    GSK-LSD1 Dihydrochloride是有效,选择性,不可逆的赖氨酸特异性脱甲基酶 (LSD1) 抑制剂,IC50 值为16 nM。
  • HY-A0091
    Pargyline hydrochlorideInhibitor 99.91%
    Pargyline盐酸盐是单胺氧化酶(MAO)不可逆性抑制剂。
  • HY-B1413
    EprobemideInhibitor 99.63%
    Eprobemide 是单胺氧化酶 A (monoamine oxidase A) 的非竞争性可逆抑制剂。
  • HY-13929
    IsocarboxazidInhibitor >98.0%
    Isocarboxazid 是一种非选择性的、不可逆的单胺氧化酶 monoamine oxidase抑制剂,其在大鼠大脑中测得的IC50 值为4.8 μM。
  • HY-W010130
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinoneInhibitor 99.37%
    7-​Hydroxy-​3,​4-​dihydro-​2(1H)​-​quinolinone 是一种弱 MAO-A抑制剂,IC50 值为 183 μM,对 MAO-B 无作用。
  • HY-N0529
    Rosmarinic acidInhibitor 99.06%
    迷迭香酸 (Rosmarinic acid) 是一种天然多酚物质,具有抗氧化、抗炎活性。
  • HY-14605
    Rasagiline mesylateInhibitor
    Rasagiline甲磺酸盐是MAO-B抑制剂,可作用于原发性帕金森病。
  • HY-16677A
    Mofegiline hydrochlorideInhibitor
    Mofegiline(MDL72974A)盐酸盐是酶活化的不可逆MAO-B抑制剂,对MAO-A和MAO-B的IC50分别为680和3.6 nM。
  • HY-N0159
    PaeonolInhibitor 99.98%
    Paeonol 是牡丹根的活性提取物,Paeonol 抑制 MAO-AMAO-BIC50 分别为 54.6 μM 和 42.5 μM。
  • HY-70057
    SafinamideInhibitor 99.77%
    Safinamide (EMD 1195686; FCE 26743)是可逆的MAO-B抑制剂,IC50为98 nM,比对MAO-A的抑制性高5918倍。
  • HY-B0886
    Iproniazid phosphateInhibitor 99.92%
    Iproniazid是一种非选择性的,不可逆的单胺氧化酶抑制剂 (MAOI)。
  • HY-B0884
    MinaprineInhibitor
    Minaprine是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。
  • HY-B1199
    NialamideInhibitor
    Nialamide是一种非选择性的, 不可逆的单胺氧化酶抑制剂 (MAOI), 用作抗抑郁药。
  • HY-14200
    (S)-RasagilineInhibitor 99.60%
    (S)-Rasagiline (TVP1022) 是 Rasagiline 的 S 型同分异构体。
  • HY-N2336
    Rosmarinic acid racemateInhibitor 98.01%
    Rosmarinic acid racemate是Rosmarinic acid的外消旋体。Rosmarinic acid抑制MAO-A,MAO-BCOMT酶,IC50分别为50.1, 184.6 和26.7 μM。
  • HY-100027A
    Ro 41-1049 hydrochlorideInhibitor 99.96%
    Ro 41-1049盐酸盐是一种选择性的单胺氧化酶A型(MAO-A)抑制剂。
  • HY-B0884A
    Minaprine dihydrochlorideInhibitor 99.82%
    Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂,还对乙酰胆碱酯酶有微弱抑制,抗抑郁类化合物。
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