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  1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase

Na+/K+ ATPase

Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase 相关产品 (14):

Cat. No.Product NameEffectPurity
  • HY-B1049
    DigoxinInhibitor 98.92%
    Digoxin是 Na+/K+-ATPase 的有效抑制剂,临床上用于治疗心律失常和心力衰竭。
  • HY-B0542
    Ouabain OctahydrateInhibitor 99.91%
    Ouabain Octahydrate 是 Na+/K+-ATPase 抑制剂,常用于治疗充血性心力衰竭。
  • HY-15718A
    Istaroxime hydrochlorideInhibitor 99.32%
    Istaroxime hydrochloride是 Na+/K+-ATPase 抑制剂 (IC50=0.11 μM) 和肌浆/内质网钙ATP酶2 (SERCA 2) 激活剂。
  • HY-N0143
    PhlorizinInhibitor
    Phlorizin 是一种非选择性的 SGLT抑制剂,对于hSGLT1hSGLT2Ki 值分别为 300 和 39 nM。Phlorizin 也是一个 Na+/K+-ATPase 抑制剂。
  • HY-B1357
    DigitoxinInhibitor 98.23%
    Digitoxin是有效的 Na+/K+-ATPase抑制剂, EC50 值为0.78 μM。
  • HY-N2070
    AcevaltrateInhibitor 99.56%
    Acevaltrate 从 Valeriana glechomifolia中分离,抑制大鼠肾和脑半球中Na+/K+-ATP酶活性,IC50 分别为 22.8±1.1 μM 和 42.3±1.0 μM。
  • HY-12283
    RostafuroxinAntagonist
    Rostafuroxin(PST 2238)是一种抗高血压化合物Na+K ATPase拮抗剂;IC50为1.5 nM。
  • HY-N0039
    Ginsenoside Rb1Inhibitor >98.0%
    Ginsenoside Rb1 是中药 Panax ginseng 的成分。Ginsenoside 抑制 Na+, K+-ATPase活性,IC50 为 6.3±1.0 μM。Ginsenoside Rb1 也抑制 IRAK-1激活及NF-κB p65 的磷酸化。
  • HY-13719
    OleandrinInhibitor 99.84%
    Oleandrin 抑制 Na+, K+-ATPase活性,IC50 为 620 nM。
  • HY-19556
    (+)-SJ733Inhibitor 99.45%
    (+)-SJ733 是临床上治疗疟疾的候选物,也是一个 Na+-ATPase PfATP4 抑制剂。
  • HY-B1429
    ChlorpropamideInhibitor 99.24%
    Chlorpropamide是一种口服降糖剂, 用于治疗非胰岛素依赖型糖尿病 (NIDDM)。
  • HY-15718
    IstaroximeInhibitor
    Istaroxime (PST2744) 是一种有效的 Na+,K+-ATPase抑制剂,IC50 值为 0.11 μM。
  • HY-B0137A
    Prilocaine hydrochlorideInhibitor
    Prilocaine是局麻化合物。
  • HY-B0137
    PrilocaineInhibitor
    Prilocaine是局麻化合物。
Isoform Specific Products

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