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  1. PROTAC
  2. PROTAC Linker

PROTAC Linker

The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein.

Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

PROTAC Linker 相关产品 (6):

Cat. No.Product NameCAS No.PurityChemical Structure
  • HY-108370
    N33-TEG-COOH201467-81-4
    N33-TEG-COOH 是一种 PROTAC 连接桥,含有四个聚乙二醇 (PEG) 单元。详细信息请看参考文献 PMID: 26035625 中的 Compound 7。
    N33-TEG-COOH
  • HY-108371
    PROTAC Linker 11835705-53-7>98.0%
    PROTAC Linker 1 是用于将相应的酪氨酸激酶抑制剂 (TKI) 连接到 E3 募集配体的一种 PROTAC 连接桥。
    PROTAC Linker 1
  • HY-112496
    PROTAC Linker 41799506-30-1>98.0%
    PROTAC Linker 4 是一种 PROTAC 连接桥,可用于合成含氯烷烃的 PROTACs (HaloPROTACs)。
    PROTAC Linker 4
  • HY-114176
    Protac linker 52245697-83-8
    Protac linker 5是用于将酪氨酸激酶 (TKI)抑制剂连接到E3招募配体上的一种PROTAC 连接体。
    Protac linker 5
  • HY-108372
    PROTAC Linker 21835705-52-6
    PROTAC Linker 2 是用于将酪氨酸激酶 (TKI) 抑制剂连接到E3招募配体上的一种 PROTAC 连接体。
    PROTAC Linker 2
  • HY-119429
    Bis-PEG4-acid31127-85-2>98.0%
    Bis-PEG4-acid是PEG的连接桥,应用于PROTAC中。
    Bis-PEG4-acid
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