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  1. PI3K/Akt/mTOR
  2. PTEN

PTEN

PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.

PTEN 相关产品 (3):

Cat. No.Product NameEffectPurity
  • HY-13074
    VO-Ohpic trihydrateInhibitor >98.0%
    VO-Ohpic trihydrate 是一种高效的 PTEN抑制剂,IC50 为 46±10 nM。
  • HY-15842
    SF1670Inhibitor >98.0%
    SF1670 是一种有效的特异性的人第10号染色体缺失的磷酸酶及张力蛋白同源蛋白 (PTEN) 抑制剂。
  • HY-D0886
    β-Glycerol phosphate disodium salt pentahydrateInhibitor >98.0%
    β-Glycerol phosphate disodium salt pentahydrate 是磷酸酶和张力蛋白同源物 (PTEN) 的抑制剂,来自专利US 20110002877 A1。
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