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  1. Stem Cell/Wnt
  2. Porcupine

Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine 相关产品 (5):

Cat. No.Product NameEffectPurity
  • HY-17545
    LGK974Inhibitor 99.65%
    LGK974 (WNT974) 是一种有效且特异性的 Porcupine(PORCN) 抑制剂,IC50 为 0.1 nM。
  • HY-15659
    Wnt-C59Inhibitor 99.56%
    Wnt-C59 (C59)是高效可口服的 PORCN抑制剂,IC50 为 74 pM。
  • HY-100408
    GNF-6231Inhibitor 99.83%
    GNF-6231是一个强的,有选择性的,能够口服的Porcupine抑制剂能够阻止Wnt信号通路。
  • HY-15825
    IWP L6Inhibitor >98.0%
    IWP L6是高活性Porcn抑制剂,EC50为0.5 nM。
  • HY-111472
    Porcupine-IN-1Inhibitor 99.08%
    Porcupine-IN-1是有效的 porcupine抑制剂,IC50 值为0.5±0.2 nM。
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