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  1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Potassium Channel

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel 相关产品 (95):

Cat. No.Product NameEffectPurity
  • HY-100381
    Nigericin sodium saltActivator >98.0%
    Nigericin sodium salt 是从吸水链霉菌中得到的一种抗生素,作为 H+,K+ 和 Pb2+ 离子载体起作用。
  • HY-B0407A
    Chlorpromazine hydrochlorideAntagonist 99.83%
    Chlorpromazine Hydrochloride是D25HT2A钾通道钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。
  • HY-50694
    SenicapocInhibitor 99.83%
    Senicapoc (ICA-17043) 是有效,选择性的 Gardos 通道阻断剂,IC50 为11 nM。 它阻断来自人红细胞的Ca2+诱导的铷通量,IC50 值为11 nM, 抑制红细胞脱水的 IC50 为30 nM。
  • HY-15206
    GlibenclamideInhibitor >98.0%
    Glibenclamide是选择性,对ATP敏感的钾离子通道抑制剂。
  • HY-15551
    E-4031Inhibitor 98.03%
    E-4031是III类抗心律失常药,选择性地阻断hERG钾通道
  • HY-15598
    20-HETEInhibitor
    20-HETE(20-hydroxy Arachidonic Acid)是血管收缩剂,可去极化血管平滑肌。
  • HY-112705
    VU0529331Inhibitor
    VU0529331 是一种适度选择性的不含 GIRK1 的 G蛋白门控内向整流钾 (non-GIRK1/X) 通道抑制剂,在 HEK293 细胞中,对 GIRK2 和 GIRK1/2 的 EC50 值分别为 5.1 µM 和 5.2 µM,同时对 GIRK4 同源通道也有作用。
  • HY-33350
    Clofilium tosylateInhibitor 99.77%
    Clofilium tosylate 是一种钾通道 (potassium channel) 阻滞剂,作用于人早幼粒细胞白血病 (HL-60) 细胞,激活 caspase-3 而诱导凋亡。具有抗心律失常作用。
  • HY-B0604
    4-AminopyridineInhibitor 99.97%
    4-Aminopyridine是非选择性的钾离子通道阻断剂,从细胞膜的细胞质侧结合。
  • HY-N0603
    Ginsenoside Rg3Inhibitor >98.0%
    Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+hKv1.4通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 NF-κB活性和COX-2 表达。
  • HY-B0232
    DofetilideInhibitor >98.0%
    Dofetilide(Tikosyn)是III型抗心律失常药,能阻断钾离子通道。
  • HY-B0401
    TolbutamideInhibitor 99.96%
    Tolbutamide是第一代钾离子通道阻断剂,是磺酰脲类口服活性的降糖化合物。
  • HY-10015
    PAP-1Inhibitor 99.69%
    PAP-1是Kv1.3电压门控的钾离子通道抑制剂,能抑制人效应记忆T细胞增殖,EC50为2 nM。
  • HY-B1140
    DiazoxideActivator 99.99%
    Diazoxide是一种ATP敏感性的钾离子通道激活剂; 可用于治疗高胰岛素血症。
  • HY-13519
    TRAM-34Inhibitor 99.71%
    TRAM-34 是一种选择性的钙激活 K+ 通道 (IKCa1)阻断剂,Kd 为 20 nM。
  • HY-B0112
    MinoxidilActivator 99.96%
    Minoxidil(U 10858)是血管扩张剂,可做用于高血压和脱发。
  • HY-14188
    Amiodarone hydrochlorideInhibitor 99.82%
    Amiodarone is a lipophilic antiarrhythmic/antianginal drug which is able to influence the physicochemical status of biological lipid components.
  • HY-B1221
    Flufenamic acidActivator 99.92%
    Flufenamic acid 是一种非甾体类抗炎剂,能够抑制 COX的活性,激活AMPK 的活性,调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+channel),调节非选择性阳离子通道,激活钾离子通道 (K+channel) 等。
  • HY-N0451
    AcacetinInhibitor 98.43%
    Acacetin是一类治疗中重要的黄酮类化合物,它有抗氧化、抗炎、抗癌的作用。
  • HY-12496
    NS-1619Activator 99.30%
    NS-1619是 Ca2_addition_-activated K_addition_-channel选择性激动剂。
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