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  1. Apoptosis
  2. RIP kinase

RIP kinase

Receptor interacting protein 2 (RIP2), a serine/threonine kinase, is an adaptor molecule of NOD1 and NOD2, and genetic variation in this receptor is known to be associated with the severity of allergic asthma in children.

Receptor interacting protein kinase 2 (RIPK2) is critical for NOD-mediated NF-κB activation and cytokine production. WEHI-345, a selective RIPK2 kinase inhibitor, which delays RIPK2 ubiquitylation and NF-κB activation downstream of NOD engagement.

Receptor interacting protein kinase 3 (RIPK3) is a cytosolic master regulator of necroptosis. RIPK3 has an active serine/threonine kinase domain at the N-terminus, and a unique protein-protein interaction domain called the RIP homotypic interaction motif (RHIM) at the C-terminus. Both kinase activity and RHIM are indispensable for necroptosis. RIPK3 interacts with other RHIM-containing proteins such as RIPK1, Toll/interleukin-1 (IL-1) receptor domain-containing adaptor protein inducing interferon β (TRIF) or DNA-dependent activator of interferon regulatory factor (DAI). RIPK3 induces necroptosis, a type of regulated necrosis, through its kinase domain and RHIM.

RIP kinase 相关产品 (14):

Cat. No.Product NameEffectPurity
  • HY-15760
    Necrostatin-1Inhibitor 99.20%
    Necrostatin-1 (Nec-1) 是一种有效,选择性和可渗透细胞的坏死性凋亡 (necroptosis) 抑制剂,在Jurkat细胞中的 EC50 为490 nM。它通过抑制坏死性凋亡途径中的死亡域受体激酶RIP (RIP1) 起作用。
  • HY-101872
    GSK'872Inhibitor 99.65%
    GSK'872 是 RIPK3 抑制剂,高亲和力结合 RIP3 激酶结构域,IC50为1.8 nM,并抑制激酶活性,IC50为1.3 nM。
  • HY-101760
    GSK2982772Inhibitor >98.0%
    GSK2982772是有效,ATP竞争型的RIP1抑制剂,IC50值为16 nM。
  • HY-101032
    RIPA-56Inhibitor 99.86%
    RIPA-56是一种高效选择和代谢稳定的受体相互作用蛋白1 (RIP1) 抑制剂, 其中IC50值为13nM。
  • HY-18937
    WEHI-345Inhibitor 98.56%
    WEHI-345是一种有效的选择性RIPK2, IC50为0.13 μM。
  • HY-114349
    HS-1371Inhibitor 98.49%
    HS-1371是高效,ATP-competitive的受体相互作用蛋白3 (RIP3)抑制剂,IC50 为 20.8 nM。
  • HY-125466
    cRIPGBM
    cRIPGBM 是RIPGBM 的促凋亡衍生物,是通过与受体相互作用蛋白激酶2 (RIPK2)结合,诱导 GBM 肿瘤干细胞 凋亡的选择性诱导剂,对 GBM-1 细胞的 EC50 值为 68 nM。
  • HY-122909
    GSK2593074AInhibitor
    GSK2593074A (GSK’074) 是一种程序性坏死 (necroptosis) 抑制剂, 抑制 RIP1RIP3
  • HY-100339
    GSK583Inhibitor 98.07%
    GSK583 是一种高效,高选择性的 RIP2 Kinase抑制剂,其IC50 值为 5 nM。
  • HY-19764
    RIP2 kinase inhibitor 1Inhibitor 98.11%
    RIP2 kinase inhibitor 1 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂,详细信息请参考专利 WO/2014043446 A1 中的化合物 example 1。
  • HY-100131
    GSK'481Inhibitor >98.0%
    GSK'481能够在HEK293T细胞中抑制RIP1 WT S166的磷酸化。
  • HY-19761
    RIP2 kinase inhibitor 2Inhibitor 99.95%
    RIP2 kinase inhibitor 2 是一种受体相互作用蛋白-2 (RIP2) 激酶抑制剂,详细信息请参考专利 WO/2014043437 A1 中的化合物 example 9。
  • HY-103028A
    GSK963Inhibitor
    GSK963 是一种手性的、强效的、选择性的受体相互作用蛋白 1 (RIP1) 酶的抑制剂,其IC50 值为 29 nM。GSK963 对体外小鼠和人细胞的坏死具有强效和选择性的抑制作用。
  • HY-18900
    Nec-4Inhibitor
    Nec-4, 一个三环衍生物,是受体相互作用蛋白 1 (RIP1)的一个有效抑制剂,其IC50 值为 2.6 μM,Ki 值为 0.46 μM。
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