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  1. Anti-infection
  2. SARS-CoV

SARS-CoV

SARS-CoV (SARS coronavirus) is the virus that causes severe acute respiratory syndrome (SARS). Coronaviruses encode papain-like proteases (PLpro) that are often multifunctional enzymes with protease activity to process the viral replicase polyprotein and deubiquitinating (DUB)/deISGylating activity, which is hypothesized to modify the innate immune response to infection.

SARS-CoV 相关产品 (3):

Cat. No.Product NameEffectPurity
  • HY-13765
    6-ThioguanineInhibitor >98.0%
    6-Thioguanine (Thioguanine) 是一种抗白血病和免疫抑制剂,为 SARS 和 MERS 冠状病毒木瓜样蛋白酶 (PLpros) 的抑制剂,同时可有效抑制 USP2的活性,IC50 值分别为 25 μM 和 40 μM。
  • HY-104077
    RemdesivirInhibitor 98.30%
    Remdesivir 是一种核苷类似物,具有抗病毒活性,在 HAE 细胞中,对 ARS-CoVMERS-CoVEC50 值为 74 nM,在延迟脑肿瘤细胞中,对鼠肝炎病毒的 EC50 值为 30 nM。
  • HY-17542
    PLpro inhibitorInhibitor
    PLpro inhibitor是PLpro抑制剂,IC50为2.6 uM。
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