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  1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

STAT Isoform Specific Products:

  • STAT3

  • STAT5

  • STAT6

STAT 相关产品 (40):

Cat. No.Product NameEffectPurity
  • HY-12000
    AG-490Inhibitor 99.84%
    AG-490是酪氨酸激酶抑制剂,其抑制EGFRStat-3JAK2/3
  • HY-13818
    StatticInhibitor >98.0%
    Stattic是有效的 STAT3 活化和二聚化的抑制剂。
  • HY-15146
    NSC 74859Inhibitor 98.90%
    NSC 74859是选择性的 Stat3抑制剂,IC50 为86±33 μM。
  • HY-100614
    AS1517499Inhibitor 99.17%
    AS1517499 是有效的 STAT6抑制剂,IC50 为 21 nM。
  • HY-N0174
    CryptotanshinoneInhibitor 98.51%
    Cryptotanshinone是从丹参的根中提取的天然化合物,具有抗肿瘤活性。 Cryptotanshinone抑制 STAT3IC50 为4.6 μM。
  • HY-N0516
    CasticinInhibitor
    Casticin 是从蔓荆子中得到的甲氧基黄酮化合物,具有抗有丝分裂和抗炎活性。Casticin 能够抑制 STAT3 的活化。
  • HY-P1453
    CMD178Inhibitor
    CMD178 是一种重要的多肽,能够持续地通过抑制 IL-2/s IL-2Rα 信号通路来减少 Foxp3 和 STAT5 的表达。CMD 178 是 STAT5 的抑制剂, 并可抑制 Treg 细胞的发育。
  • HY-102048
    STAT5-IN-2Inhibitor
    STAT5-IN-2是 STAT5的抑制剂,在K562和KU812细胞中的EC50 分别为9 μM和5 μM。高效的抗白血病活性。
  • HY-14944
    HomoharringtonineInhibitor 99.96%
    Homoharringtonine (Omacetaxine mepesuccinate;HHT) 是具有抗肿瘤特性的细胞毒性生物碱,其通过抑制翻译延长来起作用。
  • HY-13919
    NapabucasinInhibitor >98.0%
    Napabucasin 是 STAT3 的抑制剂,抑制癌症干细胞活性。
  • HY-101853
    STAT5-IN-1Inhibitor >98.0%
    STAT5-IN-1是 STAT5 的抑制剂,对 STAT5β 亚型的 IC50 值为 47 μM。
  • HY-15312
    WP1066Inhibitor 99.67%
    WP1066 是一种新颖的 JAK2STAT3 抑制剂,对 STAT5 和 ERK1/2 也起作用,但对 JAK1 和 JAK3 没有影响。
  • HY-100493
    BP-1-102Inhibitor 99.23%
    BP-1-102 是有口服活性的转录因子 Stat3的小分子抑制剂,其IC50 值为 6.8 μM。
  • HY-B0497
    NiclosamideInhibitor
    Niclosamide是一种口服生物可利用的氯化水杨酰苯胺,具有驱虫和潜在的抗肿瘤活性。 Niclosamide可抑制STAT3,在HeLa细胞中IC50 0.25 μM,并在无细胞试验中抑制DNA复制。
  • HY-N0751
    ScutellarinInhibitor >98.0%
    Scutellarin 是从黄芩中分离到的黄酮类物质,在 HCC 细胞中,能够下调 STAT3/Girdin/Akt 信号通路,在破骨细胞中,能够抑制 RANKL 介导的 MAPK/NF-κB 信号通路。
  • HY-16975
    SH-4-54Inhibitor >98.0%
    SH-4-54是 STAT 的抑制剂,与 STAT3 和 STAT5 结合的 KDs 值分别为300,464 nM。
  • HY-112288
    C188-9Inhibitor 98.11%
    C188-9 是 Stat3的抑制剂,其Kd 值为 4.7 nM。
  • HY-N1405
    Cucurbitacin IInhibitor >98.0%
    Cucurbitacin I 是 JAK2/STAT3 的天然选择性抑制剂,并具有有效的抗肿瘤活性。
  • HY-N0193
    ArtesunateInhibitor >98.0%
    Artesunate 是 STAT-3 和输出蛋白 1 (EXP1) 的抑制剂。
  • HY-100453
    HO-3867Inhibitor 99.38%
    HO-3867是有效,选择性的 STAT3 抑制剂,有着良好的抗肿瘤活性。
Isoform Specific Products

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