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  1. Autophagy
  2. ULK

ULK

ULK1, a serine/threonine protein kinase, is an enzyme that in humans is encoded by the ULK1 gene. ULK1 is essential for the initial stages of autophagy. ULK1 is an important protein in autophagy. It is part of the ULK1-complex, which is needed in early steps of autophagosome biogenesis. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation.

ULK2 is essential for astrocyte transformation and tumor growth. ULK2 also inhibits the growth of glioma cells, which requires autophagy induction as kinase mutant of ULK2 fails to induce autophagy and inhibit growth. ULK2 and its homologue ULK1 are only down-regulated in all grades of glioma. Thus these results altogether suggest that inhibition of autophagy by ULK1/2 down-regulation is essential for glioma development.

ULK 相关产品 (7):

Cat. No.Product NameEffectPurity
  • HY-13018
    MRT67307Inhibitor 99.00%
    MRT67307是 IKKεTBK-1的双抑制剂,IC50分别为 160和19 nM。 MRT67307也可抑制ULK1和ULK2,IC50 分别为45和38 nM。
  • HY-16966
    SBI-0206965Inhibitor 98.76%
    SBI-0206965是一种强效, 选择性和细胞渗透性自噬激酶ULK1抑制剂, 抑制ULK1和ULK2激酶活性, IC50值分别为108nM和711 nM。
  • HY-100006A
    MRT68921 hydrochlorideInhibitor 99.38%
    MRT68921 hydrochloride 是 ULK1ULK2最有效的抑制剂,IC50 值分别为 2.9 nM和 1.1 nM.
  • HY-101923A
    LYN-1604 hydrochlorideAgonist 99.80%
    LYN-1604 hydrochloride是一种有效的 ULK1激动剂,EC50 值为18.94 nM。
  • HY-114490
    ULK-101Inhibitor
    ULK-101 是一个有效的、选择性的ULK1 抑制剂,其在体外测得的对ULK1和 ULK2的IC50 值分别为 1.6 nM和30 nM。ULK-101抑制自噬,使癌细胞对营养胁迫敏感。
  • HY-101923
    LYN-1604Agonist
    LYN-1604 是一种有效的 UNC-51 样激酶 1 (ULK1) 激动剂,其 EC50 值为 18.94 nM。
  • HY-100006
    MRT68921Inhibitor
    MRT68921 是 ULK1ULK2最有效的抑制剂,IC50 值分别为 2.9 nM 和 1.1 nM.
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