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  1. Vitamin D Related
  2. VD/VDR

VD/VDR

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3[1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR 相关产品 (54):

Cat. No.Product NameEffectPurity
  • HY-10002
    CalcitriolAgonist 99.81%
    Calcitriol 是活性最大的 vitamin D 代谢物,也是 vitamin D 受体 (VDR) 的激动剂。
  • HY-10001
    CalcipotriolChemical 99.77%
    Calcipotriol 是一种合成的 VitD3类似物,对vitamin D 受体具有高亲和力。
  • HY-32339
    MaxacalcitolActivator 98.83%
    Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素D3类似物和VDR样受体的配体。
  • HY-15398
    CholecalciferolActivator >98.0%
    Cholecalciferol(Vitamin D3)是维生素D的天然存在形式,代谢激活后能诱导细胞分化和癌细胞增殖。
  • HY-32351A
    Calcifediol monohydrate 99.75%
    Calcifediol monohydrate 是维生素 D3 的主要循环代谢物, 是一种竞争性抑制剂,Ki 值为 3.9 μM。
  • HY-50919
    ParicalcitolAgonist 99.95%
    Paricalcitol 是 vitamin D receptor 的激活剂,用于治疗继发性甲状旁腺功能亢进(分泌过多的甲状旁腺激素),该疾病与慢性肾功能衰竭有关。
  • HY-10001A
    Calcipotriol monohydrateActivator 99.75%
    Calcipotriol是1,25-Dihydroxyvitamin D3类似物,可作用于银屑病。
  • HY-32349
    ErcalcidiolModulator 98.93%
    Ercalcidiol 是一种 vitamin D2 代谢物,作为 vitamin D 营养状态的指标。
  • HY-15254
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3Chemical 98.71%
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 是一种Vitamin D3 衍生物。
  • HY-32350
    ErcalcitriolActivator 98.17%
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。
  • HY-32341
    SeocalcitolAgonist 98.67%
    Seocalcitol 是一种 vitamin D 类似物,作用于人骨肉瘤 MG-63 细胞,结合 vitamin D受体蛋白,Kd 为 0.27 nM。
  • HY-15157
    CalcitetrolActivator
    Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。
  • HY-10003
    AlfacalcidolActivator 99.93%
    Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3)是非选择性VDR活化剂。
  • HY-32343
    SecalciferolActivator 98.58%
    Secalciferol是维生素D的代谢物,是潜在的参与骨化作用的抗炎甾体。
  • HY-76542
    Vitamin D2Activator >98.0%
    Vitamin D2 (Ergocalciferol)是维生素D的一种形式, 通过类固醇的光化学键断裂形成的, 可用作维生素D补充剂。
  • HY-15830
    25,26-Dihydroxyvitamin D3Activator
    25,26-Dihydroxyvitamin D3是维生素D3代谢物。
  • HY-32348
    DoxercalciferolActivator 99.85%
    Doxercalciferol 是维生素 D2 类似物,为维生素 D (Vitamin D) 受体激活剂,能够抵抗肾病的进程。
  • HY-A0020
    EldecalcitolActivator 99.89%
    Eldecalcitol(ED-71; 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitamin D3)是1,25-二羟基维生素D3的类似物。
  • HY-76801
    24, 25-Dihydroxy VD2Activator 99.79%
    24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物,是合成的维生素D类似物。
  • HY-13292
    Impurity B of CalcitriolActivator
    Impurity B of Calcitriol是Calcitriol的杂质,Calcitriol是维生素D3的活性代谢物,能激活维生素D受体。
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