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  1. Stem Cell/Wnt
  2. Wnt

Wnt

The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt 相关产品 (32):

Cat. No.Product NameEffectPurity
  • HY-14428
    ICG-001Inhibitor 99.83%
    ICG-001是β-catenin/TCF介导的转录抑制剂。 它特异性结合 CREB 蛋白起作用,IC50 为3 μM。
  • HY-15597
    SalinomycinInhibitor >98.0%
    Salinomycin是具有强大的抗菌 (anti-bacterial) 活性的抗球虫药,和靶向人类癌症干细胞的新型抗癌剂。
  • HY-12238
    IWR-1Inhibitor 99.83%
    IWR-1是端锚聚合酶抑制剂,抑制Wnt/β-catenin信号传导途径。
  • HY-15659
    Wnt-C59Inhibitor 99.56%
    Wnt-C59 (C59)是高效可口服的 PORCN抑制剂,IC50 为 74 pM。
  • HY-17577
    Berberine chloride hydrateActivator 99.56%
    Berberine chloride hydrate是从一些植物中提取的生物碱,具有多种生物功能,包括胰岛素敏化,抗炎和抗氧化活性。它是 AMPK 的活化剂。
  • HY-101275
    EMT inhibitor-1Inhibitor 98.71%
    EMT inhibitor-1 是 HippoTGF-βWnt 信号通路的抑制剂,并拥有抗肿瘤活性。
  • HY-75342
    Methyl vanillateActivator >98.0%
    Methyl vanillate 是枳椇属植物中的提取物,是Wnt/β-catenin信号通路活化剂。苯甲酸酯,是香草酸的甲酯。它具有抗氧化作用。植物代谢物。
  • HY-A0293
    Pyrvinium pamoateInhibitor >98.0%
    Pyrvinium pamoate是FDA批准的抗蠕虫药物,抑制 WNT 通路信号传导。
  • HY-101916
    Heparan Sulfate
    Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞表面和细胞外基质中表达丰富。
  • HY-19987
    BML-284Activator 99.98%
    BML-284是选择性和可渗透细胞的Wnt信号传导激活剂。
  • HY-18988
    ETC-159Inhibitor 98.67%
    ETC-159是有效的,具有口服活性的 PORCN抑制剂。抑制β-catenin报告基因活性的IC50 值为2.9 nM。
  • HY-13912
    IWP-2Inhibitor
    IWP-2 抑制 Wnt加工和分泌,IC50 为 27 nM。
  • HY-100830
    NCB-0846Inhibitor 99.55%
    NCB-0846是具有口服活性的TNIK抑制剂,IC50值为21 nM。
  • HY-101090
    KYA1797KInhibitor >98.0%
    KYA1797K是有效,选择性的 Wnt/β-catenin抑制剂,IC50 值为0.75 µM。
  • HY-15721
    FH535Inhibitor 99.93%
    FH535 是 Wnt/β-cateninPPAR 的抑制剂,具有抗肿瘤活性。
  • HY-101085
    SKL2001Agonist 98.08%
    SKL2001 是 Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤活性。
  • HY-16665
    iCRT 14Inhibitor 98.90%
    iCRT 14 是一种 β-连环蛋白应答转录(CRT)抑制剂,能够抑制 Wnt 信号通路,IC50 值为 40.3 nM。
  • HY-12681
    CCT251545Inhibitor 99.34%
    CCT251545是一种口服生物有效的WNT抑制剂, IC50值为5 nM。
  • HY-N0400
    WogoninInhibitor 99.83%
    Wogonin 是一种天然黄酮类物质,能够抑制 CDK8andWnt 的活性,具有抗炎、抗肿瘤等功效。
  • HY-103705
    iCRT3Inhibitor 99.19%
    iCRT3 是 Wnt 和 β-连环蛋白应答转录 (β-catenin-responsive transcription) 的抑制剂。
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