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  1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR

iGluR

iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.

AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.

iGluR 相关产品 (97):

Cat. No.Product NameEffectPurity
  • HY-15084
    Dizocilpine MaleateAntagonist 99.98%
    Dizocilpine ((+)-MK 801) Maleate 是一种有效,选择性,非竞争性的 NMDA受体拮抗剂,Kd 值为 37.2 nM。
  • HY-15066
    CNQXAntagonist 98.05%
    CNQX (FG9065) 是高效的 AMPA/kainate 受体拮抗剂。
  • HY-17551
    NMDAAgonist >98.0%
    nMDA 是 nMDA receptor 的激动剂,能够模仿谷氨酸盐的活动。
  • HY-100714A
    D-AP5Antagonist >98.0%
    D-AP5 是一个 NMDA 受体拮抗剂。
  • HY-12882A
    Ifenprodil tartrateAntagonist
    Ifenprodil tartrate是对NR2B亚基有选择性的NMDA受体拮抗剂,IC50为0.3 μM。
  • HY-109046
    TulrampatorAgonist 99.40%
    Tulrampator (CX-1632) 是一种口服生物可利用的 AMPA 受体 (AMPAR) 正变构调节剂。具有抗抑郁作用。
  • HY-P1594A
    Dynorphin A (1-10) TFAInhibitor
    Dynorphin A (1-10) (TFA) 是一种内源性的阿片样神经肽,与 κ 阿片受体 (κ-opioid receptor) 结合。Dynorphin A (1-10) (TFA) 也阻断 NMDA激活的电流,IC50 为 42.0 μM。
  • HY-111500
    NMDAR antagonist 1Antagonist
    NMDAR antagonist 1 是一种有效且口服生物可利用的,NR2B 选择性的 NMDAR 拮抗剂。
  • HY-12294A
    PEAQX tetrasodium hydrateAntagonist 98.22%
    PEAQX(NVP-AAM 077)是NMDA受体NR2A选择性高效拮抗剂,IC50值为270nM。
  • HY-15067
    DNQXAntagonist 98.46%
    DNQX (FG 9041) 是一个AMPA受体的拮抗剂。
  • HY-B0365A
    Memantine hydrochlorideInhibitor >98.0%
    Memantine (hydrochloride) (D-145 (hydrochloride)) 是金刚胺衍生物,对 NMDA 受体有较弱到适中的亲和力, 能够抑制CYP2B6和YP2D6。
  • HY-13993A
    Ro 25-6981 MaleateInhibitor
    Ro 25-6981是包含NR2B亚基的NMDA受体选择性阻断剂,对于重组型NR1C/NR2B 和 NR1C/NR2A受体的IC50为0.009 和 52 μM。
  • HY-15069
    FanapanelAntagonist 99.93%
    Fanapanel (ZK200775) 是高选择性AMPA拮抗剂。
  • HY-15084A
    (-)-Dizocilpine Maleate 99.70%
    (-)-Dizocilpine ((-)-MK 801) Maleate 是 (+)-MK-801 的对映体,(+)-MK-801 是高效选择性,选择性的,非竞争性的 NMDA 受体拮抗剂。
  • HY-17001
    Flupirtine MaleateAntagonist 99.97%
    Flupirtine (D 9998)马来酸盐是神经元钾通道开放剂,同时具有NMDA受体拮抗剂特性。
  • HY-16312
    MDL-29951Antagonist 98.50%
    MDL-29951 是一种新颖的 nMDA receptor 拮抗剂,能够抑制体内体外甘氨酸 ([3H]glycine) 的结合,Ki 值为 0.14 μM。
  • HY-12505
    CX546Agonist 99.50%
    CX546是AMPAR受体选择性激动剂。
  • HY-15079
    TalampanelAntagonist 98.59%
    Talampanel是一种有效的选择性AMPA受体拮抗剂,是一个潜在的抗癫痫新药 (AED)。
  • HY-15068
    NBQXAntagonist 98.65%
    NBQX是高度选择性,竞争型的AMPA受体拮抗剂。
  • HY-10934
    MibampatorActivator 99.47%
    Mibampator (LY451395)是AMPA受体高选择性增强剂。
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