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  1. PROTAC
    Epigenetics
  2. SNIPER
    Epigenetic Reader Domain
  3. SNIPER(BRD)-1

SNIPER(BRD)-1 

目录号: HY-111875
产品使用指南

SNIPER(BRD)-1 由 IAP 拮抗剂 LCL-161 衍生物和 BET 抑制剂 (+)-JQ-1,通过 linker 连接组成。SNIPER(BRD)-1 通过泛素-蛋白酶体系统诱导 BRD4 降解。SNIPER(BRD)-1 也降解 cIAP1,cIAP2 和 XIAP,IC50 分别为 6.8 nM,17 nM 和 49 nM。

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SNIPER(BRD)-1 Chemical Structure

SNIPER(BRD)-1 Chemical Structure

CAS No. : 2095244-54-3

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Description

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

IC50 & Target[1]

BRD4

 

cIAP1

6.8 nM (IC50)

cIAP2

17 nM (IC50)

XIAP

49 nM (Ki)

SNIPER

 

References
  • [1].Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

Molecular Weight

1056.73

Formula

C₅₃H₆₆ClN₉O₈S₂

CAS No.

2095244-54-3

SMILES

O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • [1].Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER). Chem Pharm Bull (Tokyo). 2019 Mar 1;67(3):203-209.

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产品名称:
SNIPER(BRD)-1
目录号:
HY-111875
需求量:

SNIPER(BRD)-1

Cat. No.: HY-111875